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Angiosarcoma of the trunk of unusual presentation in an immuno-competent man.

Mebazaa A, Aounallah A, Tangour M, Moula H, El Euch D, Haouet S, Mokni M, Zitouna M, Osman AB - Indian J Dermatol (2011)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, La Rabta hospital, Tunis, Tunisia. E-mail: amebazaa@yahoo.fr.

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Sir, A 49-year-old male with no medical history, presented with a painful violaceous solitary nodule of the right side of 5 months duration... It mainly occurs in males (sex ratio of 3:1), at an average age ranging from 60 to 80 years... CA arising among younger patients is frequently associated with risk factors (i.e., pre-existing vascular malformations or lymphedematous extremities)... Typical histological features of CA include a dissecting pattern with irregular proliferation of anastomosing vascular channels lined by abnormal endothelial cells... Other described patterns are solid epithelioid/spindled pattern with the presence of islands or diffuse sheets of epithelioid or spindled cells without formation of sinusoids or vascular channels and the mixed pattern with presence of a mixture of both histologic types... A multicentric study has assessed all clinicopathologic factors of 47 cases of CA in order to determine prognostic factors predictive of outcome... The authors concluded that histological grade and mitotic activity are poor markers of clinical aggressiveness... However, tumor size, depth of tumor invasion, and completeness of surgical resection are more reliable prognostic indicators... CA has high potential of locoregional and distant metastases despite aggressive multimodal therapy, mainly because of multifocality and unapparent spread of the tumor... Our observation presents several particularities as follows: the tumor occurs in a 49-year-old immunocompetent man, with no risk factors mainly of lymphoedema; clinically, it presented as a solitary violaceous nodule of the trunk suggestive of lymphoma; and the low mitotic rate of the tumour that requires aggressive treatments as well as close follow up as in CA with high mitotic rate.

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A violaceous indurated nodule, with squamous mamillated surface of the right side
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Figure 1: A violaceous indurated nodule, with squamous mamillated surface of the right side

Mentions: A 49-year-old male with no medical history, presented with a painful violaceous solitary nodule of the right side of 5 months duration. On physical examination, a violaceous indurated nodule measuring about 3cm × 2.5cm, with squamous mamillated surface was seen on the right side [Figure 1]. Examination of the whole tegument, nails, and oral mucosa was normal. There was no lymphadenopathy and the general state was conserved. There was no evidence of exposure to radiation. Viral serology markers including HIV were negative. A work-up for locoregional or metastatic metastases was negative. A histopathological examination of a skin biopsy revealed an irregular dissecting proliferation of anastomosing vascular channels invading the whole dermis without reaching the hypodermis [Figure 2a].


Angiosarcoma of the trunk of unusual presentation in an immuno-competent man.

Mebazaa A, Aounallah A, Tangour M, Moula H, El Euch D, Haouet S, Mokni M, Zitouna M, Osman AB - Indian J Dermatol (2011)

A violaceous indurated nodule, with squamous mamillated surface of the right side
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108540&req=5

Figure 1: A violaceous indurated nodule, with squamous mamillated surface of the right side
Mentions: A 49-year-old male with no medical history, presented with a painful violaceous solitary nodule of the right side of 5 months duration. On physical examination, a violaceous indurated nodule measuring about 3cm × 2.5cm, with squamous mamillated surface was seen on the right side [Figure 1]. Examination of the whole tegument, nails, and oral mucosa was normal. There was no lymphadenopathy and the general state was conserved. There was no evidence of exposure to radiation. Viral serology markers including HIV were negative. A work-up for locoregional or metastatic metastases was negative. A histopathological examination of a skin biopsy revealed an irregular dissecting proliferation of anastomosing vascular channels invading the whole dermis without reaching the hypodermis [Figure 2a].

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, La Rabta hospital, Tunis, Tunisia. E-mail: amebazaa@yahoo.fr.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, A 49-year-old male with no medical history, presented with a painful violaceous solitary nodule of the right side of 5 months duration... It mainly occurs in males (sex ratio of 3:1), at an average age ranging from 60 to 80 years... CA arising among younger patients is frequently associated with risk factors (i.e., pre-existing vascular malformations or lymphedematous extremities)... Typical histological features of CA include a dissecting pattern with irregular proliferation of anastomosing vascular channels lined by abnormal endothelial cells... Other described patterns are solid epithelioid/spindled pattern with the presence of islands or diffuse sheets of epithelioid or spindled cells without formation of sinusoids or vascular channels and the mixed pattern with presence of a mixture of both histologic types... A multicentric study has assessed all clinicopathologic factors of 47 cases of CA in order to determine prognostic factors predictive of outcome... The authors concluded that histological grade and mitotic activity are poor markers of clinical aggressiveness... However, tumor size, depth of tumor invasion, and completeness of surgical resection are more reliable prognostic indicators... CA has high potential of locoregional and distant metastases despite aggressive multimodal therapy, mainly because of multifocality and unapparent spread of the tumor... Our observation presents several particularities as follows: the tumor occurs in a 49-year-old immunocompetent man, with no risk factors mainly of lymphoedema; clinically, it presented as a solitary violaceous nodule of the trunk suggestive of lymphoma; and the low mitotic rate of the tumour that requires aggressive treatments as well as close follow up as in CA with high mitotic rate.

No MeSH data available.


Related in: MedlinePlus