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Cutaneous metastases from gastric adenocarcinoma.

Erdemır AT, Atılganoglu U, Onsun N, Somay A - Indian J Dermatol (2011)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Istanbul Education and Research Hospital, Istanbul, Turkey. E-mail: vefaasli@hotmail.com.

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Sir, Cutaneous metastases from internal primary tumors are uncommon... Typically, they are associated with an advanced stage of the disease and a poor prognosis... Here, we describe the case of a 63-year-old man with a nodule on his neck in whom biopsy showed metastatic adenocarcinoma; subsequent endoscopic examination revealed a gastric tumor... The incidence of cutaneous metastasis from carcinomas of the upper digestive tract has been reported to be less than 1%... Umbilical metastasis, Sister Mary Joseph's nodule, is the typical site for a cutaneous tumor resulting from metastasis of gastric cancer... Apart from the umbilical metastasis, the most common clinical presentation of gastric carcinoma metastatic to the skin is as multiple discrete, slow-growing, hard nodules... However, metastatic skin tumors may appear in a zosteriform pattern, as scarring alopecia, or as epidermoid cyst–like or condyloma acuminatum–like lesions... The appearance of cutaneous metastasis has been reported to follow the diagnosis of gastric carcinoma by 3–10 years... Although cutaneous metastases usually appear late in the course of the disease, they may also rarely be the presenting sign... Internal cancer only uncommonly presents itself with skin metastasis... In conclusion, we suggest that long-standing firm and nonpainful nodules, nonhealing ulcers, or persistent indurated erythema need to be biopsied to rule out cutaneous metastasis of visceral cancer.

No MeSH data available.


Two solid, erythematous, infiltrated, well-circumscribed nodular lesions on the left side of the neck
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Figure 1: Two solid, erythematous, infiltrated, well-circumscribed nodular lesions on the left side of the neck

Mentions: There was bilateral inguinal lymhadenopathy. On the left side of his neck and in the left submandibular area there were two solid, erythematous, infiltrated, well-circumscribed nodular lesions [Figure 1]. Two other small nodules were present on the right side. Biopsy from the nodule on his neck showed epidermal acanthosis and diffuse infiltration of the dermis by polygonal/round cells with irregular nuclei and poor cytoplasm. Some of them had the typical morphology of signet-ring cells [Figure 2]. Immunohistochemical study revealed that the dermal infiltration was negative for anti-leukocyte common antigen and positive for cytokeratin.


Cutaneous metastases from gastric adenocarcinoma.

Erdemır AT, Atılganoglu U, Onsun N, Somay A - Indian J Dermatol (2011)

Two solid, erythematous, infiltrated, well-circumscribed nodular lesions on the left side of the neck
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108537&req=5

Figure 1: Two solid, erythematous, infiltrated, well-circumscribed nodular lesions on the left side of the neck
Mentions: There was bilateral inguinal lymhadenopathy. On the left side of his neck and in the left submandibular area there were two solid, erythematous, infiltrated, well-circumscribed nodular lesions [Figure 1]. Two other small nodules were present on the right side. Biopsy from the nodule on his neck showed epidermal acanthosis and diffuse infiltration of the dermis by polygonal/round cells with irregular nuclei and poor cytoplasm. Some of them had the typical morphology of signet-ring cells [Figure 2]. Immunohistochemical study revealed that the dermal infiltration was negative for anti-leukocyte common antigen and positive for cytokeratin.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Istanbul Education and Research Hospital, Istanbul, Turkey. E-mail: vefaasli@hotmail.com.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Cutaneous metastases from internal primary tumors are uncommon... Typically, they are associated with an advanced stage of the disease and a poor prognosis... Here, we describe the case of a 63-year-old man with a nodule on his neck in whom biopsy showed metastatic adenocarcinoma; subsequent endoscopic examination revealed a gastric tumor... The incidence of cutaneous metastasis from carcinomas of the upper digestive tract has been reported to be less than 1%... Umbilical metastasis, Sister Mary Joseph's nodule, is the typical site for a cutaneous tumor resulting from metastasis of gastric cancer... Apart from the umbilical metastasis, the most common clinical presentation of gastric carcinoma metastatic to the skin is as multiple discrete, slow-growing, hard nodules... However, metastatic skin tumors may appear in a zosteriform pattern, as scarring alopecia, or as epidermoid cyst–like or condyloma acuminatum–like lesions... The appearance of cutaneous metastasis has been reported to follow the diagnosis of gastric carcinoma by 3–10 years... Although cutaneous metastases usually appear late in the course of the disease, they may also rarely be the presenting sign... Internal cancer only uncommonly presents itself with skin metastasis... In conclusion, we suggest that long-standing firm and nonpainful nodules, nonhealing ulcers, or persistent indurated erythema need to be biopsied to rule out cutaneous metastasis of visceral cancer.

No MeSH data available.