Limits...
Lupus miliaris disseminatus faciei with unusual distribution of lesions.

Nath AK, Sivaranjini R, Thappa DM, Basu D - Indian J Dermatol (2011)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry - 605 006, India. E-mail: dmthappa@gmail.com.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly localized on the face... There was no history of sexual promiscuity or any genital ulcer disease in the past... He did not suffer from any medical problem... Typical skin lesions of LMDF are multiple discrete, smooth, 1-3 mm, monomorphic, symmetrical reddish-brown or brown-to-yellowish dome-shaped translucent papules and nodules occurring on the chin, forehead, cheeks, and eyelids... Several other sites like axillae, chest, neck, arms, hands, legs, and groin have been reported to be rarely involved in LMDF... Characteristic histopathology includes a tubercle consisting of aggregates of epithelioid histiocytes and occasional multinucleate giant cells, which surround a usually large area of caseous necrosis... This typical histopathological feature, however, is not consistently seen... Caseation necrosis is variable and usually seen in fully developed LMDF lesions... Shitara delineated the histopathological findings into four groups: epithelioid cell granuloma with central necrosis, epithelioid cell granuloma without central necrosis (sarcoid/foreign body reaction), epithelioid cell granuloma with abscesses, and nongranulomatous nonspecific inflammatory infiltrate... Therapy is difficult with variable efficacy and several therapeutic modalities, e.g., dapsone, doxycycline, minocycline, isotretinoin, clofazimine, isoniazid, and corticosteroids have been used to effectively induce remission... Topical agents such as psoralen with ultraviolet A therapy (PUVA), erythromycin and metronidazole have also been used... Considering LMDF a condition related to rosacea, it may be worthwhile trying oral nicomide containing nicotinamide and zinc, which has been found to be an effective therapy in rosacea... Topical tacrolimus, on the other hand may induce rosacea like dermatitis.

No MeSH data available.


Related in: MedlinePlus

(a) Papules and nodules of LMDF over the face and neck. (b) Close up of neck
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3108536&req=5

Figure 1: (a) Papules and nodules of LMDF over the face and neck. (b) Close up of neck

Mentions: A 36-year-old male presented with 4 months history of asymptomatic, reddish-raised lesions over the face, earlobes, and the neck. The lesions initially appeared on the chin and left side of the neck, which progressively involved his forehead, both the cheeks, earlobes, upper eyelids, and whole of his neck over a period of 2 months. He works in biscuit wrapper manufacturing unit; but there is no history of contact with any chemical or fumes. His wife was treated (6 months treatment) for tuberculous lymphadenitis a year back; but he himself never had cough, expectoration, hemoptysis, or weight loss. There was no history of sexual promiscuity or any genital ulcer disease in the past. He did not suffer from any medical problem. On examination, multiple, erythematous, firm papules and nodules of size ranging from 0.5 to 2 cm were seen on forehead, upper eyelids, malar region, nose, beard area, chin, earlobes, submandibular region, the entire neck and shoulder [Figure 1a–b]. A few lesions showed scaling on the surface. These lesions were larger and more coalescent on the neck. Diascopy revealed apple-jelly appearance in some of the lesions. There was no cervical lymphadenopathy. Tuberculin test was negative. Chest X-ray was unremarkable. Venereal disease research laboratory (VDRL) test was non-reactive. Biopsy from a representative skin nodule showed mild epidermal hyperplasia and granulomatous reaction pattern in the dermis. Granulomas were composed of epithelioid cells, plenty of Langhan's and foreign body giant cells surrounded by a lymphocytic cuff [Figure 2]. Extensive caseous necrosis was seen in the center of multiple granulomas [Figures 3 and 4]. A tendency toward periappendageal localization of the granulomas was also noted. Stain for acid-fast bacilli and fungi were negative. A final diagnosis of lupus miliaris disseminatus faciei was made based on the above-mentioned features. A trial of anti-tubercular therapy was given for 2 months, but no response was seen, rather he had developed some new lesions (including one papule on the right upper chest). He was put on minocycline 100 mg daily and is under follow up.


Lupus miliaris disseminatus faciei with unusual distribution of lesions.

Nath AK, Sivaranjini R, Thappa DM, Basu D - Indian J Dermatol (2011)

(a) Papules and nodules of LMDF over the face and neck. (b) Close up of neck
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108536&req=5

Figure 1: (a) Papules and nodules of LMDF over the face and neck. (b) Close up of neck
Mentions: A 36-year-old male presented with 4 months history of asymptomatic, reddish-raised lesions over the face, earlobes, and the neck. The lesions initially appeared on the chin and left side of the neck, which progressively involved his forehead, both the cheeks, earlobes, upper eyelids, and whole of his neck over a period of 2 months. He works in biscuit wrapper manufacturing unit; but there is no history of contact with any chemical or fumes. His wife was treated (6 months treatment) for tuberculous lymphadenitis a year back; but he himself never had cough, expectoration, hemoptysis, or weight loss. There was no history of sexual promiscuity or any genital ulcer disease in the past. He did not suffer from any medical problem. On examination, multiple, erythematous, firm papules and nodules of size ranging from 0.5 to 2 cm were seen on forehead, upper eyelids, malar region, nose, beard area, chin, earlobes, submandibular region, the entire neck and shoulder [Figure 1a–b]. A few lesions showed scaling on the surface. These lesions were larger and more coalescent on the neck. Diascopy revealed apple-jelly appearance in some of the lesions. There was no cervical lymphadenopathy. Tuberculin test was negative. Chest X-ray was unremarkable. Venereal disease research laboratory (VDRL) test was non-reactive. Biopsy from a representative skin nodule showed mild epidermal hyperplasia and granulomatous reaction pattern in the dermis. Granulomas were composed of epithelioid cells, plenty of Langhan's and foreign body giant cells surrounded by a lymphocytic cuff [Figure 2]. Extensive caseous necrosis was seen in the center of multiple granulomas [Figures 3 and 4]. A tendency toward periappendageal localization of the granulomas was also noted. Stain for acid-fast bacilli and fungi were negative. A final diagnosis of lupus miliaris disseminatus faciei was made based on the above-mentioned features. A trial of anti-tubercular therapy was given for 2 months, but no response was seen, rather he had developed some new lesions (including one papule on the right upper chest). He was put on minocycline 100 mg daily and is under follow up.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry - 605 006, India. E-mail: dmthappa@gmail.com.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly localized on the face... There was no history of sexual promiscuity or any genital ulcer disease in the past... He did not suffer from any medical problem... Typical skin lesions of LMDF are multiple discrete, smooth, 1-3 mm, monomorphic, symmetrical reddish-brown or brown-to-yellowish dome-shaped translucent papules and nodules occurring on the chin, forehead, cheeks, and eyelids... Several other sites like axillae, chest, neck, arms, hands, legs, and groin have been reported to be rarely involved in LMDF... Characteristic histopathology includes a tubercle consisting of aggregates of epithelioid histiocytes and occasional multinucleate giant cells, which surround a usually large area of caseous necrosis... This typical histopathological feature, however, is not consistently seen... Caseation necrosis is variable and usually seen in fully developed LMDF lesions... Shitara delineated the histopathological findings into four groups: epithelioid cell granuloma with central necrosis, epithelioid cell granuloma without central necrosis (sarcoid/foreign body reaction), epithelioid cell granuloma with abscesses, and nongranulomatous nonspecific inflammatory infiltrate... Therapy is difficult with variable efficacy and several therapeutic modalities, e.g., dapsone, doxycycline, minocycline, isotretinoin, clofazimine, isoniazid, and corticosteroids have been used to effectively induce remission... Topical agents such as psoralen with ultraviolet A therapy (PUVA), erythromycin and metronidazole have also been used... Considering LMDF a condition related to rosacea, it may be worthwhile trying oral nicomide containing nicotinamide and zinc, which has been found to be an effective therapy in rosacea... Topical tacrolimus, on the other hand may induce rosacea like dermatitis.

No MeSH data available.


Related in: MedlinePlus