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Facial nodule in a 34-year-old man.

Puri P, Singh A, Ramesh V - Indian J Dermatol (2011)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Safdarjang Hospital and Vardhman Mahavir Medical College, New Delhi - 110 029, India.

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The peripheral layer of cells merged with the stroma that stained strongly with alcian blue... What is your diagnosis? Chondroid syringoma Chondroid syringoma (CS), also called as mixed tumor of skin, is a benign cutaneous adnexal tumor composed of epithelial and stromal elements and is predominantly seen in the head and neck regions... CS are usually benign but may rarely undergo malignant transformation... The malignant forms may arise de novo or may arise from incompletely excised lesion that has recurred... Although the diameter of malignant CS is usually more than 3 cm (range, 2–8 cm; mean, 4.8 cm), giant benign facial CS have also been reported... Therefore, lesions more than 3 cm in diameter should be followed up carefully on account of malignancy... The choice of management is complete surgical excision with a cuff of normal tissue, rather than simple shelling of lesion... To conclude, CS should be considered in the differential diagnosis of a nodular lesion on the skin of head and neck regions... Due to its rarity, the diagnosis is often overlooked, especially when considered preoperatively.

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Biphasic tumor composed of myxochondroid stroma and epithelial component. (H and E, × 200)
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Figure 3: Biphasic tumor composed of myxochondroid stroma and epithelial component. (H and E, × 200)

Mentions: Microscopic examination of the excised lesion showed a well-circumscribed tumor located in the deep dermis and seen extending into subcutaneous tissue [Figure 2]. A biphasic growth pattern could be readily appreciated and consisted of epithelial component embedded in a mixture of abundant fibrous and myxochondroid stroma [Figure 3]. The epithelial component consisted of branching and nonbranching tubules, cords, and dilated cystic structures with secretions in their lumina. The tubules demonstrated an eccrine differentiation, with lining of luminal layer with cuboidal cells and a peripheral layer of flattened cells. The peripheral layer of cells merged with the stroma that stained strongly with alcian blue.


Facial nodule in a 34-year-old man.

Puri P, Singh A, Ramesh V - Indian J Dermatol (2011)

Biphasic tumor composed of myxochondroid stroma and epithelial component. (H and E, × 200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108533&req=5

Figure 3: Biphasic tumor composed of myxochondroid stroma and epithelial component. (H and E, × 200)
Mentions: Microscopic examination of the excised lesion showed a well-circumscribed tumor located in the deep dermis and seen extending into subcutaneous tissue [Figure 2]. A biphasic growth pattern could be readily appreciated and consisted of epithelial component embedded in a mixture of abundant fibrous and myxochondroid stroma [Figure 3]. The epithelial component consisted of branching and nonbranching tubules, cords, and dilated cystic structures with secretions in their lumina. The tubules demonstrated an eccrine differentiation, with lining of luminal layer with cuboidal cells and a peripheral layer of flattened cells. The peripheral layer of cells merged with the stroma that stained strongly with alcian blue.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Safdarjang Hospital and Vardhman Mahavir Medical College, New Delhi - 110 029, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The peripheral layer of cells merged with the stroma that stained strongly with alcian blue... What is your diagnosis? Chondroid syringoma Chondroid syringoma (CS), also called as mixed tumor of skin, is a benign cutaneous adnexal tumor composed of epithelial and stromal elements and is predominantly seen in the head and neck regions... CS are usually benign but may rarely undergo malignant transformation... The malignant forms may arise de novo or may arise from incompletely excised lesion that has recurred... Although the diameter of malignant CS is usually more than 3 cm (range, 2–8 cm; mean, 4.8 cm), giant benign facial CS have also been reported... Therefore, lesions more than 3 cm in diameter should be followed up carefully on account of malignancy... The choice of management is complete surgical excision with a cuff of normal tissue, rather than simple shelling of lesion... To conclude, CS should be considered in the differential diagnosis of a nodular lesion on the skin of head and neck regions... Due to its rarity, the diagnosis is often overlooked, especially when considered preoperatively.

No MeSH data available.


Related in: MedlinePlus