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Periungual Basal cell carcinoma: a case report with review of literature.

Bandyopadhyay D, Sen S - Indian J Dermatol (2011)

Bottom Line: Early diagnosis can enable the physician to render simpler nondestructive modalities of treatment.In this article, we describe such a case of longstanding BCC of this region mimicking a traumatic ulcer.The nature of the ailment was finally discovered on biopsy and the carcinoma was initially treated with topical Imiquimod.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, R.G. Kar Medical College, Kolkata, India.

ABSTRACT
Basal cell carcinomas (BCCs) are considered to be uncommon around the nail plate. An indolent lesion of this region should arouse suspicion of potential malignancy and a skin biopsy should be undertaken without delay. Early diagnosis can enable the physician to render simpler nondestructive modalities of treatment. In this article, we describe such a case of longstanding BCC of this region mimicking a traumatic ulcer. The nature of the ailment was finally discovered on biopsy and the carcinoma was initially treated with topical Imiquimod.

No MeSH data available.


Related in: MedlinePlus

Basaloid cells in upper dermis in a case of periungual BCC (H and E, 10×)
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Figure 2: Basaloid cells in upper dermis in a case of periungual BCC (H and E, 10×)

Mentions: Routine blood, stool and urine examinations were normal as was the chest X-ray. A 3-mm punch biopsy of lesional skin was performed and histopathology revealed presence of solid islands of basaloid cells in upper dermis without much pleomorphism and without any mitotic figure [Figure 2]. Palisading was absent. There were no horn cysts. The subject was instructed to apply topical Imiquimod (5%) cream with the help of cotton tipped sterile tooth pick over the affected area at bedtime, 5 times a week, washing it off the next morning. Each sachet of Imiquimod contained 12.5 g of the drug and the patient had to use up this amount in a week. Treatment was prescribed for 6 weeks and he had to report every 15 days. Four weeks after starting the drug, the person returned complaining of intense pruritus, erythema, and some pain. He was unwilling to continue topical Imiquimod, was extremely anxious as he had come to know of the biopsy report and was referred to the surgery department for suitable operative maneuver. The case was lost to follow-up.


Periungual Basal cell carcinoma: a case report with review of literature.

Bandyopadhyay D, Sen S - Indian J Dermatol (2011)

Basaloid cells in upper dermis in a case of periungual BCC (H and E, 10×)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108529&req=5

Figure 2: Basaloid cells in upper dermis in a case of periungual BCC (H and E, 10×)
Mentions: Routine blood, stool and urine examinations were normal as was the chest X-ray. A 3-mm punch biopsy of lesional skin was performed and histopathology revealed presence of solid islands of basaloid cells in upper dermis without much pleomorphism and without any mitotic figure [Figure 2]. Palisading was absent. There were no horn cysts. The subject was instructed to apply topical Imiquimod (5%) cream with the help of cotton tipped sterile tooth pick over the affected area at bedtime, 5 times a week, washing it off the next morning. Each sachet of Imiquimod contained 12.5 g of the drug and the patient had to use up this amount in a week. Treatment was prescribed for 6 weeks and he had to report every 15 days. Four weeks after starting the drug, the person returned complaining of intense pruritus, erythema, and some pain. He was unwilling to continue topical Imiquimod, was extremely anxious as he had come to know of the biopsy report and was referred to the surgery department for suitable operative maneuver. The case was lost to follow-up.

Bottom Line: Early diagnosis can enable the physician to render simpler nondestructive modalities of treatment.In this article, we describe such a case of longstanding BCC of this region mimicking a traumatic ulcer.The nature of the ailment was finally discovered on biopsy and the carcinoma was initially treated with topical Imiquimod.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, R.G. Kar Medical College, Kolkata, India.

ABSTRACT
Basal cell carcinomas (BCCs) are considered to be uncommon around the nail plate. An indolent lesion of this region should arouse suspicion of potential malignancy and a skin biopsy should be undertaken without delay. Early diagnosis can enable the physician to render simpler nondestructive modalities of treatment. In this article, we describe such a case of longstanding BCC of this region mimicking a traumatic ulcer. The nature of the ailment was finally discovered on biopsy and the carcinoma was initially treated with topical Imiquimod.

No MeSH data available.


Related in: MedlinePlus