Limits...
Hyaline cell-rich chondroid syringoma of the finger.

Ramaswamy AS, Yenni VV, Wilfred C, Manjunatha HK, Shilpa K - Indian J Dermatol (2011)

Bottom Line: A mixed tumor is a neoplasm that has microscopic features of both epithelial and mesenchymal differentiation.These tumors commonly occur in the head and neck region of middle-aged men.Although very few cases have been reported in literature, it is important to be aware of this entity so as to avoid misdiagnosis on histopathological examination.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, PES Institute of Medical Sciences and Research, Kuppam, Bangalore, India.

ABSTRACT
A mixed tumor is a neoplasm that has microscopic features of both epithelial and mesenchymal differentiation. Such mixed tumors are known as pleomorphic adenomas in the salivary glands, and their cutaneous counterparts are called chondroid syringomas. These tumors commonly occur in the head and neck region of middle-aged men. Hyaline cell-rich chondroid syringoma is a rare benign variant of chondroid syringoma composed of cells with eosinophilic hyaline cytoplasm and plasmacytoid features, the origin of which remains elusive. Although very few cases have been reported in literature, it is important to be aware of this entity so as to avoid misdiagnosis on histopathological examination. In this report we present a case of hyaline cell-rich chondroid syringoma occurring in the finger.

No MeSH data available.


Related in: MedlinePlus

Tubuloalveolar structures lined by bi layered epithelium (H and E; 400×)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3108528&req=5

Figure 3: Tubuloalveolar structures lined by bi layered epithelium (H and E; 400×)

Mentions: Histopathological examination revealed a well-circumscribed proliferation of epithelial cells interspersed with foci of fibrous, myxoid, and chondroid stroma [Figures 1a and 1b]. Most of these cells, which were arranged in broad sheets and nests, had a plasmacytoid appearance with an ovoid eccentric nucleus having fine granular chromatin and a deeply eosinophilic ′hyaline-like′ cytoplasm [Figure 2]. Interconnecting tubuloalveolar structures lined by two layers of cuboidal epithelial cells and ductal structures lined by one- to two-layered epithelial cells were also evident [Figure 3]. Focal keratinous differentiation in the form of a keratinous cyst was also noted. The stroma showed intense positivity with periodic acid-Schiff (PAS) and alcian blue stain and metachromatic staining with toluidine blue. This constellation of findings led to the diagnosis of hyaline cell–rich chondroid syringoma.


Hyaline cell-rich chondroid syringoma of the finger.

Ramaswamy AS, Yenni VV, Wilfred C, Manjunatha HK, Shilpa K - Indian J Dermatol (2011)

Tubuloalveolar structures lined by bi layered epithelium (H and E; 400×)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108528&req=5

Figure 3: Tubuloalveolar structures lined by bi layered epithelium (H and E; 400×)
Mentions: Histopathological examination revealed a well-circumscribed proliferation of epithelial cells interspersed with foci of fibrous, myxoid, and chondroid stroma [Figures 1a and 1b]. Most of these cells, which were arranged in broad sheets and nests, had a plasmacytoid appearance with an ovoid eccentric nucleus having fine granular chromatin and a deeply eosinophilic ′hyaline-like′ cytoplasm [Figure 2]. Interconnecting tubuloalveolar structures lined by two layers of cuboidal epithelial cells and ductal structures lined by one- to two-layered epithelial cells were also evident [Figure 3]. Focal keratinous differentiation in the form of a keratinous cyst was also noted. The stroma showed intense positivity with periodic acid-Schiff (PAS) and alcian blue stain and metachromatic staining with toluidine blue. This constellation of findings led to the diagnosis of hyaline cell–rich chondroid syringoma.

Bottom Line: A mixed tumor is a neoplasm that has microscopic features of both epithelial and mesenchymal differentiation.These tumors commonly occur in the head and neck region of middle-aged men.Although very few cases have been reported in literature, it is important to be aware of this entity so as to avoid misdiagnosis on histopathological examination.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, PES Institute of Medical Sciences and Research, Kuppam, Bangalore, India.

ABSTRACT
A mixed tumor is a neoplasm that has microscopic features of both epithelial and mesenchymal differentiation. Such mixed tumors are known as pleomorphic adenomas in the salivary glands, and their cutaneous counterparts are called chondroid syringomas. These tumors commonly occur in the head and neck region of middle-aged men. Hyaline cell-rich chondroid syringoma is a rare benign variant of chondroid syringoma composed of cells with eosinophilic hyaline cytoplasm and plasmacytoid features, the origin of which remains elusive. Although very few cases have been reported in literature, it is important to be aware of this entity so as to avoid misdiagnosis on histopathological examination. In this report we present a case of hyaline cell-rich chondroid syringoma occurring in the finger.

No MeSH data available.


Related in: MedlinePlus