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Scle-lp overlap syndrome.

Sekar CS, Rai R, Karthika N, Laila A - Indian J Dermatol (2011)

Bottom Line: A 35-year-old female presented with scaly annular and pigmented lesions all over the body of 2 years duration.Her clinical features, histopathology, immunofluorescence findings and positive ANA and anti-Ro antibodies were suggestive of subacute cutaneous lupus erythematosus-lichen planus.We report this case because of its clinical rarity.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, PSG Hospitals, Coimbatore, India.

ABSTRACT
A 35-year-old female presented with scaly annular and pigmented lesions all over the body of 2 years duration. Her clinical features, histopathology, immunofluorescence findings and positive ANA and anti-Ro antibodies were suggestive of subacute cutaneous lupus erythematosus-lichen planus. We report this case because of its clinical rarity.

No MeSH data available.


Related in: MedlinePlus

Hyperkeratosis with basal cell degeneration, colloid bodies, and pigmentary incontinence (H and E, 10×)
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Figure 3: Hyperkeratosis with basal cell degeneration, colloid bodies, and pigmentary incontinence (H and E, 10×)

Mentions: Her complete blood count, liver and renal function tests were normal. ANA and Anti- Ro antibodies were positive. Lupus anticoagulant, anti cardiolipin antibody, VDRL, and HIV ELISA were negative. Histopathology revealed epidermis with hyperkeratosis, follicular plugging and basal vacuolar damage. Few civatte bodies were seen in the epidermis and superficial dermis [Figure 3]. The superficial dermis was edematous and showed mucin deposits with perivascular lymhocytic infiltrate and melanophages. Direct immunofluorescence showed linear deposits of fibrinogen at the basement membrane zone. With the history and investigations, a diagnosis of SCLE-LP overlap syndrome was made. She was administered oral steroids and hydroxychloroquine and the lesions subsided.


Scle-lp overlap syndrome.

Sekar CS, Rai R, Karthika N, Laila A - Indian J Dermatol (2011)

Hyperkeratosis with basal cell degeneration, colloid bodies, and pigmentary incontinence (H and E, 10×)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108525&req=5

Figure 3: Hyperkeratosis with basal cell degeneration, colloid bodies, and pigmentary incontinence (H and E, 10×)
Mentions: Her complete blood count, liver and renal function tests were normal. ANA and Anti- Ro antibodies were positive. Lupus anticoagulant, anti cardiolipin antibody, VDRL, and HIV ELISA were negative. Histopathology revealed epidermis with hyperkeratosis, follicular plugging and basal vacuolar damage. Few civatte bodies were seen in the epidermis and superficial dermis [Figure 3]. The superficial dermis was edematous and showed mucin deposits with perivascular lymhocytic infiltrate and melanophages. Direct immunofluorescence showed linear deposits of fibrinogen at the basement membrane zone. With the history and investigations, a diagnosis of SCLE-LP overlap syndrome was made. She was administered oral steroids and hydroxychloroquine and the lesions subsided.

Bottom Line: A 35-year-old female presented with scaly annular and pigmented lesions all over the body of 2 years duration.Her clinical features, histopathology, immunofluorescence findings and positive ANA and anti-Ro antibodies were suggestive of subacute cutaneous lupus erythematosus-lichen planus.We report this case because of its clinical rarity.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, PSG Hospitals, Coimbatore, India.

ABSTRACT
A 35-year-old female presented with scaly annular and pigmented lesions all over the body of 2 years duration. Her clinical features, histopathology, immunofluorescence findings and positive ANA and anti-Ro antibodies were suggestive of subacute cutaneous lupus erythematosus-lichen planus. We report this case because of its clinical rarity.

No MeSH data available.


Related in: MedlinePlus