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Multiple generalized xanthogranuloma in adult: case report and treatment.

Achar A, Naskar B, Mondal PC, Pal M - Indian J Dermatol (2011)

Bottom Line: The patient was put on isotretinoin 20 mg once daily.Most of the lesions subsided or flattened within two months of isotretinoin therapy.This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Midnapore Medical College, West Bengal, India.

ABSTRACT
Xanthogranuloma is a benign, asymptomatic, and self-healing disorder of non-Langerhans cell histiocytosis, affecting mostly infants, children, and rarely adults. Diagnosis is easy in typical cases but become more complex in unusual forms. We report a case of a 28-year-old male patient who presented with multiple diffuse brown-to-yellowish papulonodular eruptions over extremities, ears, face, trunk, and extensors of joints with almost bilaterally symmetrical distribution for a period of one month. Histopathological examination of the skin biopsy specimen revealed features of xanthogranuloma. The patient was put on isotretinoin 20 mg once daily. Most of the lesions subsided or flattened within two months of isotretinoin therapy. This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy. But further study is required to observe the effectiveness of isotretinoin in xanthogranuloma.

No MeSH data available.


Related in: MedlinePlus

Post-treatment photograph after one month of treatment
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Figure 3: Post-treatment photograph after one month of treatment

Mentions: The prognosis of disease was discussed with patient. As there was a diffuse involvement with disfigurement, we planed to give some treatment to improve disease process rapidly. We started isotretinoin 20 mg once daily after food. Patient was reviewed after one month and noted about 50% reduction of size of lesion [Figure 3]. He continued treatment for another one month and noticed that most of the lesions had flattened with yellowish and hyperpigmented macules [Figure 4]. Repeat lipid profile and liver function test was done and no abnormalities were detected.


Multiple generalized xanthogranuloma in adult: case report and treatment.

Achar A, Naskar B, Mondal PC, Pal M - Indian J Dermatol (2011)

Post-treatment photograph after one month of treatment
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108521&req=5

Figure 3: Post-treatment photograph after one month of treatment
Mentions: The prognosis of disease was discussed with patient. As there was a diffuse involvement with disfigurement, we planed to give some treatment to improve disease process rapidly. We started isotretinoin 20 mg once daily after food. Patient was reviewed after one month and noted about 50% reduction of size of lesion [Figure 3]. He continued treatment for another one month and noticed that most of the lesions had flattened with yellowish and hyperpigmented macules [Figure 4]. Repeat lipid profile and liver function test was done and no abnormalities were detected.

Bottom Line: The patient was put on isotretinoin 20 mg once daily.Most of the lesions subsided or flattened within two months of isotretinoin therapy.This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Midnapore Medical College, West Bengal, India.

ABSTRACT
Xanthogranuloma is a benign, asymptomatic, and self-healing disorder of non-Langerhans cell histiocytosis, affecting mostly infants, children, and rarely adults. Diagnosis is easy in typical cases but become more complex in unusual forms. We report a case of a 28-year-old male patient who presented with multiple diffuse brown-to-yellowish papulonodular eruptions over extremities, ears, face, trunk, and extensors of joints with almost bilaterally symmetrical distribution for a period of one month. Histopathological examination of the skin biopsy specimen revealed features of xanthogranuloma. The patient was put on isotretinoin 20 mg once daily. Most of the lesions subsided or flattened within two months of isotretinoin therapy. This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy. But further study is required to observe the effectiveness of isotretinoin in xanthogranuloma.

No MeSH data available.


Related in: MedlinePlus