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Multiple generalized xanthogranuloma in adult: case report and treatment.

Achar A, Naskar B, Mondal PC, Pal M - Indian J Dermatol (2011)

Bottom Line: The patient was put on isotretinoin 20 mg once daily.Most of the lesions subsided or flattened within two months of isotretinoin therapy.This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Midnapore Medical College, West Bengal, India.

ABSTRACT
Xanthogranuloma is a benign, asymptomatic, and self-healing disorder of non-Langerhans cell histiocytosis, affecting mostly infants, children, and rarely adults. Diagnosis is easy in typical cases but become more complex in unusual forms. We report a case of a 28-year-old male patient who presented with multiple diffuse brown-to-yellowish papulonodular eruptions over extremities, ears, face, trunk, and extensors of joints with almost bilaterally symmetrical distribution for a period of one month. Histopathological examination of the skin biopsy specimen revealed features of xanthogranuloma. The patient was put on isotretinoin 20 mg once daily. Most of the lesions subsided or flattened within two months of isotretinoin therapy. This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy. But further study is required to observe the effectiveness of isotretinoin in xanthogranuloma.

No MeSH data available.


Related in: MedlinePlus

Granulomatous dermal infiltrates of foam cells, giant cells (Touton type), histiocytes, lymphocytes, neutrophils. [H & E stain; original magnifications: 2b ×10; 2a and c ×40]
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Figure 2: Granulomatous dermal infiltrates of foam cells, giant cells (Touton type), histiocytes, lymphocytes, neutrophils. [H & E stain; original magnifications: 2b ×10; 2a and c ×40]

Mentions: Histopathological examination revealed dense granulomatous dermal infiltrates consisting of foam cells, giant cells (mainly Touton type), histiocytes, lymphocytes, and a few eosinophils and neutrophils mainly at upper dermis. The epidermis was thinned out without any grenz zone and inflammatory cells extended toward lower dermis to subcutaneous tissue [Figure 2a–c. A pathological confirmation of xanthogranuloma was made. X-ray of chest and skull were normal. Ultrasonography of abdomen and pelvis showed no visceral involvement.


Multiple generalized xanthogranuloma in adult: case report and treatment.

Achar A, Naskar B, Mondal PC, Pal M - Indian J Dermatol (2011)

Granulomatous dermal infiltrates of foam cells, giant cells (Touton type), histiocytes, lymphocytes, neutrophils. [H & E stain; original magnifications: 2b ×10; 2a and c ×40]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108521&req=5

Figure 2: Granulomatous dermal infiltrates of foam cells, giant cells (Touton type), histiocytes, lymphocytes, neutrophils. [H & E stain; original magnifications: 2b ×10; 2a and c ×40]
Mentions: Histopathological examination revealed dense granulomatous dermal infiltrates consisting of foam cells, giant cells (mainly Touton type), histiocytes, lymphocytes, and a few eosinophils and neutrophils mainly at upper dermis. The epidermis was thinned out without any grenz zone and inflammatory cells extended toward lower dermis to subcutaneous tissue [Figure 2a–c. A pathological confirmation of xanthogranuloma was made. X-ray of chest and skull were normal. Ultrasonography of abdomen and pelvis showed no visceral involvement.

Bottom Line: The patient was put on isotretinoin 20 mg once daily.Most of the lesions subsided or flattened within two months of isotretinoin therapy.This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Midnapore Medical College, West Bengal, India.

ABSTRACT
Xanthogranuloma is a benign, asymptomatic, and self-healing disorder of non-Langerhans cell histiocytosis, affecting mostly infants, children, and rarely adults. Diagnosis is easy in typical cases but become more complex in unusual forms. We report a case of a 28-year-old male patient who presented with multiple diffuse brown-to-yellowish papulonodular eruptions over extremities, ears, face, trunk, and extensors of joints with almost bilaterally symmetrical distribution for a period of one month. Histopathological examination of the skin biopsy specimen revealed features of xanthogranuloma. The patient was put on isotretinoin 20 mg once daily. Most of the lesions subsided or flattened within two months of isotretinoin therapy. This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy. But further study is required to observe the effectiveness of isotretinoin in xanthogranuloma.

No MeSH data available.


Related in: MedlinePlus