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Multiple generalized xanthogranuloma in adult: case report and treatment.

Achar A, Naskar B, Mondal PC, Pal M - Indian J Dermatol (2011)

Bottom Line: The patient was put on isotretinoin 20 mg once daily.Most of the lesions subsided or flattened within two months of isotretinoin therapy.This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Midnapore Medical College, West Bengal, India.

ABSTRACT
Xanthogranuloma is a benign, asymptomatic, and self-healing disorder of non-Langerhans cell histiocytosis, affecting mostly infants, children, and rarely adults. Diagnosis is easy in typical cases but become more complex in unusual forms. We report a case of a 28-year-old male patient who presented with multiple diffuse brown-to-yellowish papulonodular eruptions over extremities, ears, face, trunk, and extensors of joints with almost bilaterally symmetrical distribution for a period of one month. Histopathological examination of the skin biopsy specimen revealed features of xanthogranuloma. The patient was put on isotretinoin 20 mg once daily. Most of the lesions subsided or flattened within two months of isotretinoin therapy. This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy. But further study is required to observe the effectiveness of isotretinoin in xanthogranuloma.

No MeSH data available.


Related in: MedlinePlus

Yellow-brown relatively well-demarcated shiny elastic papulonodular eruptions
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Figure 1: Yellow-brown relatively well-demarcated shiny elastic papulonodular eruptions

Mentions: A 28-year-old healthy male patient presented in our department with one-month history of diffuse numerous papulonodular eruptions at extremities, ears, face, and trunk. The majority of lesions were present over extensors of joints. The lesions developed suddenly at first over right leg with mild itching. No other constitutional symptom was present. Cutaneous examination revealed yellow-brown, relatively well-demarcated papulonodular lesions with variable sizes (1–5 mm in diameter). Lesions were shiny, soft to elastic in consistency consistency present almost all over the body and majority being over upper and lower extremities, ears, and chin [Figure 1a–c]. The surface of some lesions were scaly. There was no vesiculation, erosion, or crusting. The mucous membranes, palms and soles were unaffected and ophthalmologic examination was normal. No other systemic involvement was noted. No other family members were affected.


Multiple generalized xanthogranuloma in adult: case report and treatment.

Achar A, Naskar B, Mondal PC, Pal M - Indian J Dermatol (2011)

Yellow-brown relatively well-demarcated shiny elastic papulonodular eruptions
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108521&req=5

Figure 1: Yellow-brown relatively well-demarcated shiny elastic papulonodular eruptions
Mentions: A 28-year-old healthy male patient presented in our department with one-month history of diffuse numerous papulonodular eruptions at extremities, ears, face, and trunk. The majority of lesions were present over extensors of joints. The lesions developed suddenly at first over right leg with mild itching. No other constitutional symptom was present. Cutaneous examination revealed yellow-brown, relatively well-demarcated papulonodular lesions with variable sizes (1–5 mm in diameter). Lesions were shiny, soft to elastic in consistency consistency present almost all over the body and majority being over upper and lower extremities, ears, and chin [Figure 1a–c]. The surface of some lesions were scaly. There was no vesiculation, erosion, or crusting. The mucous membranes, palms and soles were unaffected and ophthalmologic examination was normal. No other systemic involvement was noted. No other family members were affected.

Bottom Line: The patient was put on isotretinoin 20 mg once daily.Most of the lesions subsided or flattened within two months of isotretinoin therapy.This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Midnapore Medical College, West Bengal, India.

ABSTRACT
Xanthogranuloma is a benign, asymptomatic, and self-healing disorder of non-Langerhans cell histiocytosis, affecting mostly infants, children, and rarely adults. Diagnosis is easy in typical cases but become more complex in unusual forms. We report a case of a 28-year-old male patient who presented with multiple diffuse brown-to-yellowish papulonodular eruptions over extremities, ears, face, trunk, and extensors of joints with almost bilaterally symmetrical distribution for a period of one month. Histopathological examination of the skin biopsy specimen revealed features of xanthogranuloma. The patient was put on isotretinoin 20 mg once daily. Most of the lesions subsided or flattened within two months of isotretinoin therapy. This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy. But further study is required to observe the effectiveness of isotretinoin in xanthogranuloma.

No MeSH data available.


Related in: MedlinePlus