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Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus

The leg has all white hairs and no repigmentation is visible except in one spot (arrows and circle)
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Figure 23: The leg has all white hairs and no repigmentation is visible except in one spot (arrows and circle)

Mentions: Finally, it is well known among those who are interested in vitiligo that treatment is difficult and frustrating. Some of the areas of depigmentation are especially difficult to repigment, such as the hands and feet. It seems mysterious to many. However, it has been shown that the hair follicle is the reservoir for repigmentation.[87–93] Nature, for reasons not clear, evolved skin on the fingers, ventral surface of the wrist, the feet and genitalia that is hairless, i.e., glabrous. Such skin or skin with white hairs cannot respond to medical treatment [Figures 22 and 23] but only to surgical treatments which are a means to make a reservoir where there was none.


Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

The leg has all white hairs and no repigmentation is visible except in one spot (arrows and circle)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108518&req=5

Figure 23: The leg has all white hairs and no repigmentation is visible except in one spot (arrows and circle)
Mentions: Finally, it is well known among those who are interested in vitiligo that treatment is difficult and frustrating. Some of the areas of depigmentation are especially difficult to repigment, such as the hands and feet. It seems mysterious to many. However, it has been shown that the hair follicle is the reservoir for repigmentation.[87–93] Nature, for reasons not clear, evolved skin on the fingers, ventral surface of the wrist, the feet and genitalia that is hairless, i.e., glabrous. Such skin or skin with white hairs cannot respond to medical treatment [Figures 22 and 23] but only to surgical treatments which are a means to make a reservoir where there was none.

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus