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Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus

The neck of an African woman who had vitiligo for over 20 years. She was a farmer and worked in the sun daily. Note the elastosis of the neck, but the normal overlying white epidermis
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Figure 19: The neck of an African woman who had vitiligo for over 20 years. She was a farmer and worked in the sun daily. Note the elastosis of the neck, but the normal overlying white epidermis

Mentions: It is of note that actinic damage also is less visible in white skin than in the pigmented skin of those with vitiligo [Figures 19 and 20].[608082–84] Several studies on patients with vitiligo treated with PUVA showed no increase in skin cancer incidence.[70828586] In contrast, albinos exhibit sun damage from early childhood.[626365] Some white skin caused by the absence of melanocytes from other causes seems susceptible to carcinogenesis. Thermal scars or depigmented skin of patients with discoid lupus are susceptible to formation of cancers. Of particular interest are patients with piebaldism caused by defects in the c-kit oncogene. As noted above, piebald skin reacts differently from normally pigmented skin to a graft versus host immune reaction.[47] In my own series of three families with piebaldism, actinic damage is common and seems to have a predilection for the white skin rather than the pigmented normal skin [Figure 21]. This seems to be the reverse of our observations for vitiligo skin. That the melanocytes have some role in inflammation, carcinogenesis and other processes seems probable.


Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

The neck of an African woman who had vitiligo for over 20 years. She was a farmer and worked in the sun daily. Note the elastosis of the neck, but the normal overlying white epidermis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108518&req=5

Figure 19: The neck of an African woman who had vitiligo for over 20 years. She was a farmer and worked in the sun daily. Note the elastosis of the neck, but the normal overlying white epidermis
Mentions: It is of note that actinic damage also is less visible in white skin than in the pigmented skin of those with vitiligo [Figures 19 and 20].[608082–84] Several studies on patients with vitiligo treated with PUVA showed no increase in skin cancer incidence.[70828586] In contrast, albinos exhibit sun damage from early childhood.[626365] Some white skin caused by the absence of melanocytes from other causes seems susceptible to carcinogenesis. Thermal scars or depigmented skin of patients with discoid lupus are susceptible to formation of cancers. Of particular interest are patients with piebaldism caused by defects in the c-kit oncogene. As noted above, piebald skin reacts differently from normally pigmented skin to a graft versus host immune reaction.[47] In my own series of three families with piebaldism, actinic damage is common and seems to have a predilection for the white skin rather than the pigmented normal skin [Figure 21]. This seems to be the reverse of our observations for vitiligo skin. That the melanocytes have some role in inflammation, carcinogenesis and other processes seems probable.

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus