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Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus

Mice with mivit/mivit gene. The mouse on the left has a piebald band on the leg but a normal pigmented pelage in early life. The mouse on the right is undergoing depigmentation with loss of melanocytes from the epidermis and hair follicles
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Figure 18: Mice with mivit/mivit gene. The mouse on the left has a piebald band on the leg but a normal pigmented pelage in early life. The mouse on the right is undergoing depigmentation with loss of melanocytes from the epidermis and hair follicles

Mentions: A muted response to contact allergens is not unique to humans. There is a species of mice that has an acquired form of depigmentation resembling vitiligo, called the mi/mivit/vit mouse [Figure 18].[4849] The skin and follicles of the mouse have normal numbers of Langerhans cells in both the pigmented and depigmented stages.[50] However, the response of the mouse to potent contact allergens is highly muted after the skin and pelage have lost their melanocytes.[5152] This aberrant response might be due to inability of depigmented skin to express intercellular adhesion molecule 1 (ICAM-1).[53] Humans with vitiligo show altered expression of ICAM-1 in the epidermis. ICAM-1 is critical to a normal immune response.[5455]


Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

Mice with mivit/mivit gene. The mouse on the left has a piebald band on the leg but a normal pigmented pelage in early life. The mouse on the right is undergoing depigmentation with loss of melanocytes from the epidermis and hair follicles
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108518&req=5

Figure 18: Mice with mivit/mivit gene. The mouse on the left has a piebald band on the leg but a normal pigmented pelage in early life. The mouse on the right is undergoing depigmentation with loss of melanocytes from the epidermis and hair follicles
Mentions: A muted response to contact allergens is not unique to humans. There is a species of mice that has an acquired form of depigmentation resembling vitiligo, called the mi/mivit/vit mouse [Figure 18].[4849] The skin and follicles of the mouse have normal numbers of Langerhans cells in both the pigmented and depigmented stages.[50] However, the response of the mouse to potent contact allergens is highly muted after the skin and pelage have lost their melanocytes.[5152] This aberrant response might be due to inability of depigmented skin to express intercellular adhesion molecule 1 (ICAM-1).[53] Humans with vitiligo show altered expression of ICAM-1 in the epidermis. ICAM-1 is critical to a normal immune response.[5455]

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus