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Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus

A woman treated with monobenzone, who developed a contact allergy. The dermatitis is exclusively confined to the pigmented skin
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Figure 16: A woman treated with monobenzone, who developed a contact allergy. The dermatitis is exclusively confined to the pigmented skin

Mentions: Others have noted that depigmented skin does not respond to contact allergens.[41–44] Monobenzone as noted above is used to depigment skin for those with depigmentation too widespread to repigment. Some individuals applying monobenzone develop a contact allergy to the medication [Figures 16 and 17]. However, the allergic dermatitis is manifested only in the pigmented skin.[45] In separate studies, investigators observed that the inflammatory response to irritants was abnormal in white skin compared to pigmented skin.[46] It seems especially fascinating that graft versus host skin disease in one individual with piebaldism affected preferentially the white skin,[47] emphasizing again that the three cells of the epidermis work together and that melanocytes likely play a role in inflammation.


Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

A woman treated with monobenzone, who developed a contact allergy. The dermatitis is exclusively confined to the pigmented skin
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108518&req=5

Figure 16: A woman treated with monobenzone, who developed a contact allergy. The dermatitis is exclusively confined to the pigmented skin
Mentions: Others have noted that depigmented skin does not respond to contact allergens.[41–44] Monobenzone as noted above is used to depigment skin for those with depigmentation too widespread to repigment. Some individuals applying monobenzone develop a contact allergy to the medication [Figures 16 and 17]. However, the allergic dermatitis is manifested only in the pigmented skin.[45] In separate studies, investigators observed that the inflammatory response to irritants was abnormal in white skin compared to pigmented skin.[46] It seems especially fascinating that graft versus host skin disease in one individual with piebaldism affected preferentially the white skin,[47] emphasizing again that the three cells of the epidermis work together and that melanocytes likely play a role in inflammation.

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus