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Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus

The epidermis is composed of three main cell types that work together like a troika
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Figure 15: The epidermis is composed of three main cell types that work together like a troika

Mentions: The three cells of the epidermis, keratinocytes, Langerhans cells and melanocytes, form a troika so to speak [Figure 15] and work together.[25] As noted above, it should not be surprising that depigmented skin has some altered functions if one part of the troika is missing. Several Japanese workers noted that depigmented skin of vitiligo patients did not react to sensitization with dinitrofluoro benzene (DNFB) to produce contact dermatitis.[3839] In their experiments, DNFB was applied to normal skin to induce contact allergy. A challenge was applied to both normal and white skin. The white skin did not respond. In other experiments, the sensitizing dose of DNFB was applied to white skin and the challenge to both white and pigmented skin. The pigmented but not the white skin responded.[38] These findings suggest that the afferent limb of the immune response is intact in the white skin, but the efferent limb is not so. In the same studies, Candida antigen was injected into the dermis of both white and pigmented skin and the dermal response was normal in both.[39] The discrepancy between epidermal and dermal immune responses might be attributed to loss of the melanocytes which could have immune/inflammatory functions.[2540]


Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

The epidermis is composed of three main cell types that work together like a troika
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108518&req=5

Figure 15: The epidermis is composed of three main cell types that work together like a troika
Mentions: The three cells of the epidermis, keratinocytes, Langerhans cells and melanocytes, form a troika so to speak [Figure 15] and work together.[25] As noted above, it should not be surprising that depigmented skin has some altered functions if one part of the troika is missing. Several Japanese workers noted that depigmented skin of vitiligo patients did not react to sensitization with dinitrofluoro benzene (DNFB) to produce contact dermatitis.[3839] In their experiments, DNFB was applied to normal skin to induce contact allergy. A challenge was applied to both normal and white skin. The white skin did not respond. In other experiments, the sensitizing dose of DNFB was applied to white skin and the challenge to both white and pigmented skin. The pigmented but not the white skin responded.[38] These findings suggest that the afferent limb of the immune response is intact in the white skin, but the efferent limb is not so. In the same studies, Candida antigen was injected into the dermis of both white and pigmented skin and the dermal response was normal in both.[39] The discrepancy between epidermal and dermal immune responses might be attributed to loss of the melanocytes which could have immune/inflammatory functions.[2540]

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus