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Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus

An Indian woman with veloce vitiligo. She lost almost all of her pigmentation on the skin and hair over a period of some months
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Figure 14: An Indian woman with veloce vitiligo. She lost almost all of her pigmentation on the skin and hair over a period of some months

Mentions: Typically, bilateral vitiligo progresses over the life of the individual so that the person has partially normal and partially depigmented skin. This probably is the worst outcome. Of course, it is best to be one's own color but it is the worst condition for most people to have two colors at least on visible skin such as the hands, face, neck and arms. To avoid this, for some patients, the treatment of choice is depigmentation of the normal skin by applications of monobenzone by which they achieve a single color. This is what Michael Jackson did to achieve a single white color. Occasionally, nature achieves the same end. A very small number of patients will develop over a period of a few months a very rapid depigmentation of the entire integument and also the hair [Figure 14]. Dr. Aaron Lerner called it “veloce vitiligo” or rapid vitiligo. These individuals go from having dark skin to having totally depigmented skin and hair in a period of months. It can occur spontaneously but in my personal experience has followed in a few individuals generalized erythematous drug eruptions. How or why this happens is not known.


Vitiligo: a review of some facts lesser known about depigmentation.

Nordlund JJ - Indian J Dermatol (2011)

An Indian woman with veloce vitiligo. She lost almost all of her pigmentation on the skin and hair over a period of some months
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108518&req=5

Figure 14: An Indian woman with veloce vitiligo. She lost almost all of her pigmentation on the skin and hair over a period of some months
Mentions: Typically, bilateral vitiligo progresses over the life of the individual so that the person has partially normal and partially depigmented skin. This probably is the worst outcome. Of course, it is best to be one's own color but it is the worst condition for most people to have two colors at least on visible skin such as the hands, face, neck and arms. To avoid this, for some patients, the treatment of choice is depigmentation of the normal skin by applications of monobenzone by which they achieve a single color. This is what Michael Jackson did to achieve a single white color. Occasionally, nature achieves the same end. A very small number of patients will develop over a period of a few months a very rapid depigmentation of the entire integument and also the hair [Figure 14]. Dr. Aaron Lerner called it “veloce vitiligo” or rapid vitiligo. These individuals go from having dark skin to having totally depigmented skin and hair in a period of months. It can occur spontaneously but in my personal experience has followed in a few individuals generalized erythematous drug eruptions. How or why this happens is not known.

Bottom Line: It has three important factors underlying this destruction.The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment.The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wright State Boonshoft School of Medicine, Dayton, Ohio, USA.

ABSTRACT
Vitiligo is a disorder that causes the destruction of melanocytes. It has three important factors underlying this destruction. The depigmented skin has many aberrant functions such as a muted response to contact allergens, a phenomenon also seen in mice that depigment. The white skin of those with vitiligo does not form non-melanoma skin cancers although the white skin of albinos, which has a similar color as vitiligo, is highly susceptible to skin cancer.

No MeSH data available.


Related in: MedlinePlus