Limits...
Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.

Atkinson J - Front Pharmacol (2011)

Bottom Line: This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation.It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality.This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Laboratory, Pharmacy Faculty, Nancy University Villers, France.

ABSTRACT
This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality. It then goes on to consider background studies on the relationship between inhibition of the RAAS and stroke. This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

No MeSH data available.


Related in: MedlinePlus

Increases in arterial distensibility produced by the ACEI, lisinopril (recalculated and redrawn from Makki et al., 1994). Four-month-old normotensive rats were treated orally for 9 months with a low dose of lisinopril (0.9 mg/kg/day) or a high dose (9 mg/kg/day). ACE was inhibited in a dose-related fashion but the low dose treatment did not significantly modify systolic blood pressure (A). Arterial stiffness (judged from the relationship between pulse wave velocity and mean blood pressure) was reduced in a dose-dependent fashion (B) and this was probably due in part to a reduction in the loss of thickness of arterial elastic fibers with age (C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3108479&req=5

Figure 4: Increases in arterial distensibility produced by the ACEI, lisinopril (recalculated and redrawn from Makki et al., 1994). Four-month-old normotensive rats were treated orally for 9 months with a low dose of lisinopril (0.9 mg/kg/day) or a high dose (9 mg/kg/day). ACE was inhibited in a dose-related fashion but the low dose treatment did not significantly modify systolic blood pressure (A). Arterial stiffness (judged from the relationship between pulse wave velocity and mean blood pressure) was reduced in a dose-dependent fashion (B) and this was probably due in part to a reduction in the loss of thickness of arterial elastic fibers with age (C).

Mentions: Angiotensin I converting enzyme inhibitors may be useful in this context as they appear to protect the elastic fiber network of the arterial wall and reduced the age-related increase in wall stiffness (Figure 4).


Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.

Atkinson J - Front Pharmacol (2011)

Increases in arterial distensibility produced by the ACEI, lisinopril (recalculated and redrawn from Makki et al., 1994). Four-month-old normotensive rats were treated orally for 9 months with a low dose of lisinopril (0.9 mg/kg/day) or a high dose (9 mg/kg/day). ACE was inhibited in a dose-related fashion but the low dose treatment did not significantly modify systolic blood pressure (A). Arterial stiffness (judged from the relationship between pulse wave velocity and mean blood pressure) was reduced in a dose-dependent fashion (B) and this was probably due in part to a reduction in the loss of thickness of arterial elastic fibers with age (C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108479&req=5

Figure 4: Increases in arterial distensibility produced by the ACEI, lisinopril (recalculated and redrawn from Makki et al., 1994). Four-month-old normotensive rats were treated orally for 9 months with a low dose of lisinopril (0.9 mg/kg/day) or a high dose (9 mg/kg/day). ACE was inhibited in a dose-related fashion but the low dose treatment did not significantly modify systolic blood pressure (A). Arterial stiffness (judged from the relationship between pulse wave velocity and mean blood pressure) was reduced in a dose-dependent fashion (B) and this was probably due in part to a reduction in the loss of thickness of arterial elastic fibers with age (C).
Mentions: Angiotensin I converting enzyme inhibitors may be useful in this context as they appear to protect the elastic fiber network of the arterial wall and reduced the age-related increase in wall stiffness (Figure 4).

Bottom Line: This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation.It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality.This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Laboratory, Pharmacy Faculty, Nancy University Villers, France.

ABSTRACT
This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality. It then goes on to consider background studies on the relationship between inhibition of the RAAS and stroke. This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

No MeSH data available.


Related in: MedlinePlus