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Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.

Atkinson J - Front Pharmacol (2011)

Bottom Line: This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation.It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality.This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Laboratory, Pharmacy Faculty, Nancy University Villers, France.

ABSTRACT
This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality. It then goes on to consider background studies on the relationship between inhibition of the RAAS and stroke. This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

No MeSH data available.


Related in: MedlinePlus

Possible pressure-dependent (A) and pressure-independent (B) effects of antihypertensive drugs on the cerebral circulation and stroke.
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Figure 1: Possible pressure-dependent (A) and pressure-independent (B) effects of antihypertensive drugs on the cerebral circulation and stroke.

Mentions: The fact that lowering blood pressure with a wide range of drugs with very different mechanisms of action has a beneficial effect on stroke occurrence, would argue that the important factor is lowering blood pressure rather than the pharmacological way in which this is done (Figure 1). This is backed up by epidemiological data showing that stroke occurrence, survival and recurrence are all affected by high blood pressure (Sacco et al., 1982).


Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.

Atkinson J - Front Pharmacol (2011)

Possible pressure-dependent (A) and pressure-independent (B) effects of antihypertensive drugs on the cerebral circulation and stroke.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108479&req=5

Figure 1: Possible pressure-dependent (A) and pressure-independent (B) effects of antihypertensive drugs on the cerebral circulation and stroke.
Mentions: The fact that lowering blood pressure with a wide range of drugs with very different mechanisms of action has a beneficial effect on stroke occurrence, would argue that the important factor is lowering blood pressure rather than the pharmacological way in which this is done (Figure 1). This is backed up by epidemiological data showing that stroke occurrence, survival and recurrence are all affected by high blood pressure (Sacco et al., 1982).

Bottom Line: This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation.It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality.This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Laboratory, Pharmacy Faculty, Nancy University Villers, France.

ABSTRACT
This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality. It then goes on to consider background studies on the relationship between inhibition of the RAAS and stroke. This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

No MeSH data available.


Related in: MedlinePlus