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Beneficial effects of anisodamine in shock involved cholinergic anti-inflammatory pathway.

Zhao T, Li DJ, Liu C, Su DF, Shen FM - Front Pharmacol (2011)

Bottom Line: The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation.Here, we suggest a new mechanism for its anti-shock effect.That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University Shanghai, China.

ABSTRACT
Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation. Here, we suggest a new mechanism for its anti-shock effect. That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway.

No MeSH data available.


Related in: MedlinePlus

Chemical structures of anisodamine and atropine.
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Figure 2: Chemical structures of anisodamine and atropine.

Mentions: Anisodamine, a belladonna alkaloid isolated from the Chinese medicinal herb Scopolia tangutica Maxim (Figure 1) of the Solanaceae family indigenous to Tibet and first synthesized by Chinese scientists in 1975, is an ester formed by the combination of tropic acid and the organic base tropine, and is related to atropine with a hydroxyl group at the asymmetric carbon position six of the tropine radical (Figure 2). It is generally considered as an antagonist of muscarinic receptor in the textbook of Pharmacology for medical students in China (Yang and Su, 2008), and has been used therapeutically to improve blood flow in circulatory disorders such as septic shock and disseminated intravascular coagulation since 1965. Studies found that anisodamine significantly reduced the mortality rate of toxic bacillary dysentery from 20–30 to 0.5% and fulminant epidemic meningitis from 66.9 to 12.4% in humans (Anonymous, 1975; Wang and Kuo, 1978; Xiu, 1980). In different kinds of shock models prepared from either rabbit, or cat, or rat, induced by late hemorrhage, superior mesenteric artery occlusion, septic shock from peritonitis, and traumatic shock, anisodamine significantly alleviated the progress of shock and increased the survival rate of the animals than that of other commonly used vasoactive drugs, such as norepinephrine, phenoxybenzamine, dopamine, and aramine (Hock et al., 1983; Su et al., 1983, 1984).


Beneficial effects of anisodamine in shock involved cholinergic anti-inflammatory pathway.

Zhao T, Li DJ, Liu C, Su DF, Shen FM - Front Pharmacol (2011)

Chemical structures of anisodamine and atropine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108475&req=5

Figure 2: Chemical structures of anisodamine and atropine.
Mentions: Anisodamine, a belladonna alkaloid isolated from the Chinese medicinal herb Scopolia tangutica Maxim (Figure 1) of the Solanaceae family indigenous to Tibet and first synthesized by Chinese scientists in 1975, is an ester formed by the combination of tropic acid and the organic base tropine, and is related to atropine with a hydroxyl group at the asymmetric carbon position six of the tropine radical (Figure 2). It is generally considered as an antagonist of muscarinic receptor in the textbook of Pharmacology for medical students in China (Yang and Su, 2008), and has been used therapeutically to improve blood flow in circulatory disorders such as septic shock and disseminated intravascular coagulation since 1965. Studies found that anisodamine significantly reduced the mortality rate of toxic bacillary dysentery from 20–30 to 0.5% and fulminant epidemic meningitis from 66.9 to 12.4% in humans (Anonymous, 1975; Wang and Kuo, 1978; Xiu, 1980). In different kinds of shock models prepared from either rabbit, or cat, or rat, induced by late hemorrhage, superior mesenteric artery occlusion, septic shock from peritonitis, and traumatic shock, anisodamine significantly alleviated the progress of shock and increased the survival rate of the animals than that of other commonly used vasoactive drugs, such as norepinephrine, phenoxybenzamine, dopamine, and aramine (Hock et al., 1983; Su et al., 1983, 1984).

Bottom Line: The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation.Here, we suggest a new mechanism for its anti-shock effect.That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University Shanghai, China.

ABSTRACT
Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation. Here, we suggest a new mechanism for its anti-shock effect. That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway.

No MeSH data available.


Related in: MedlinePlus