Limits...
Bilateral giant juvenile fibroadenomas of breasts:a case report.

Nikumbh DB, Desai SR, Madan PS, Patil NJ, Wader JV - Patholog Res Int (2011)

Bottom Line: To the best of our knowledge, we are presenting the fifth case of bilateral giant juvenile fibroadenomas in a 12-year-old prepubertal girl.The diagnosis was made on fine-needle aspiration cytology which was confirmed on histopathology.In this paper, we present this rare case to illustrate the diagnosis and management of this tumour and to emphasize that these tumours are almost always benign and should be treated with breast-conserving surgery to provide a healthy physical and social life to the patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Krishna Institute of Medical Sciences, Karad, District Satara, Maharashtra 415110, India.

ABSTRACT
Juvenile fibroadenoma constitutes only 4% of the total fibroadenomas. The incidence of giant juvenile fibroadenomas is found to be only 0.5% of all the fibroadenomas. Bilateral giant juvenile fibroadenomas are extremely rare, and only four cases have been reported in the literature. To the best of our knowledge, we are presenting the fifth case of bilateral giant juvenile fibroadenomas in a 12-year-old prepubertal girl. The diagnosis was made on fine-needle aspiration cytology which was confirmed on histopathology. In this paper, we present this rare case to illustrate the diagnosis and management of this tumour and to emphasize that these tumours are almost always benign and should be treated with breast-conserving surgery to provide a healthy physical and social life to the patient.

No MeSH data available.


Related in: MedlinePlus

Light microscopy showed well-encapsulated tumor with hyperplasia of both epithelial and stromal components. (H&E stain X100).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3108471&req=5

fig5: Light microscopy showed well-encapsulated tumor with hyperplasia of both epithelial and stromal components. (H&E stain X100).

Mentions: Hematoxylin- and eosin-stained sections revealed well-encapsulated tumors with hyperplasia of both epithelial and stromal components. Epithelial component showed tubular or tufted pattern of epithelial hyperplasia with characteristic tufts of cells protruding into the lumina (Figure 5). The glands were lined by bilayered epithelium at places showing stratification. Most of the areas in both the tumors showed a pericanalicular pattern of fibroadenoma. Stroma was cellular and showed myxoid change (Figure 6). Though stromal cellularity was increased, there was no leaf-like growth pattern and focal periductal concentrate of cells which was the characteristic of phyllodes tumor. There was occasional mitosis (0-1/hpf) and absence of cytological atypia. The final histopathological diagnosis of Bilateral Giant Juvenile Fibroadenomas of breasts was given. The patient is on regular followup and doing well at six-month followup.


Bilateral giant juvenile fibroadenomas of breasts:a case report.

Nikumbh DB, Desai SR, Madan PS, Patil NJ, Wader JV - Patholog Res Int (2011)

Light microscopy showed well-encapsulated tumor with hyperplasia of both epithelial and stromal components. (H&E stain X100).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108471&req=5

fig5: Light microscopy showed well-encapsulated tumor with hyperplasia of both epithelial and stromal components. (H&E stain X100).
Mentions: Hematoxylin- and eosin-stained sections revealed well-encapsulated tumors with hyperplasia of both epithelial and stromal components. Epithelial component showed tubular or tufted pattern of epithelial hyperplasia with characteristic tufts of cells protruding into the lumina (Figure 5). The glands were lined by bilayered epithelium at places showing stratification. Most of the areas in both the tumors showed a pericanalicular pattern of fibroadenoma. Stroma was cellular and showed myxoid change (Figure 6). Though stromal cellularity was increased, there was no leaf-like growth pattern and focal periductal concentrate of cells which was the characteristic of phyllodes tumor. There was occasional mitosis (0-1/hpf) and absence of cytological atypia. The final histopathological diagnosis of Bilateral Giant Juvenile Fibroadenomas of breasts was given. The patient is on regular followup and doing well at six-month followup.

Bottom Line: To the best of our knowledge, we are presenting the fifth case of bilateral giant juvenile fibroadenomas in a 12-year-old prepubertal girl.The diagnosis was made on fine-needle aspiration cytology which was confirmed on histopathology.In this paper, we present this rare case to illustrate the diagnosis and management of this tumour and to emphasize that these tumours are almost always benign and should be treated with breast-conserving surgery to provide a healthy physical and social life to the patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Krishna Institute of Medical Sciences, Karad, District Satara, Maharashtra 415110, India.

ABSTRACT
Juvenile fibroadenoma constitutes only 4% of the total fibroadenomas. The incidence of giant juvenile fibroadenomas is found to be only 0.5% of all the fibroadenomas. Bilateral giant juvenile fibroadenomas are extremely rare, and only four cases have been reported in the literature. To the best of our knowledge, we are presenting the fifth case of bilateral giant juvenile fibroadenomas in a 12-year-old prepubertal girl. The diagnosis was made on fine-needle aspiration cytology which was confirmed on histopathology. In this paper, we present this rare case to illustrate the diagnosis and management of this tumour and to emphasize that these tumours are almost always benign and should be treated with breast-conserving surgery to provide a healthy physical and social life to the patient.

No MeSH data available.


Related in: MedlinePlus