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Oral carcinogenesis and oral cancer chemoprevention: a review.

Tanaka T, Tanaka M, Tanaka T - Patholog Res Int (2011)

Bottom Line: The rationale for molecular-targeted prevention of oral cancer is promising.In addition, novel chemopreventive agents based on molecular mechanisms and targets against oral cancers will be derived from studies using appropriate animal carcinogenesis models.New approaches, such as molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy.

View Article: PubMed Central - PubMed

Affiliation: Director TCI-CaRP, 5-1-2 Minami-Uzura, Gifu City, Gifu 500-8285, Japan.

ABSTRACT
Oral cancer is one of the major global threats to public health. The development of oral cancer is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. The rationale for molecular-targeted prevention of oral cancer is promising. Biomarkers of genomic instability, including aneuploidy and allelic imbalance, are possible to measure the cancer risk of oral premalignancies. Understanding of the biology of oral carcinogenesis will yield important advances for detecting high-risk patients, monitoring preventive interventions, and assessing cancer risk and pharmacogenomics. In addition, novel chemopreventive agents based on molecular mechanisms and targets against oral cancers will be derived from studies using appropriate animal carcinogenesis models. New approaches, such as molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy.

No MeSH data available.


Related in: MedlinePlus

The natural history of oral carcinogenesis.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: The natural history of oral carcinogenesis.

Mentions: Oral carcinogenesis is a highly complex multifocal process that takes place when squamous epithelium is affected by several genetic alterations. The use of several molecular biology techniques to diagnose oral precancerous lesions and cancer may markedly improve the early detection of alterations that are invisible under the microscope. This would identify patients at a high risk of developing oral cancer [11]. The natural history of oral cancer and sequence of genetic alterations are illustrated in Figure 1. There are several approaches to understanding the molecular basis of oral cancer [12–14]. They include microarray technology, methylation microarrays, gene expression microarrays, array comparative genomic hybridization, proteomics, mitochondrial arrays, and micro-RNA arrays [15]. High-throughput approaches are currently being used to search for oral cancer biomarkers in biofluids, such as saliva and serum [15].


Oral carcinogenesis and oral cancer chemoprevention: a review.

Tanaka T, Tanaka M, Tanaka T - Patholog Res Int (2011)

The natural history of oral carcinogenesis.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108384&req=5

fig1: The natural history of oral carcinogenesis.
Mentions: Oral carcinogenesis is a highly complex multifocal process that takes place when squamous epithelium is affected by several genetic alterations. The use of several molecular biology techniques to diagnose oral precancerous lesions and cancer may markedly improve the early detection of alterations that are invisible under the microscope. This would identify patients at a high risk of developing oral cancer [11]. The natural history of oral cancer and sequence of genetic alterations are illustrated in Figure 1. There are several approaches to understanding the molecular basis of oral cancer [12–14]. They include microarray technology, methylation microarrays, gene expression microarrays, array comparative genomic hybridization, proteomics, mitochondrial arrays, and micro-RNA arrays [15]. High-throughput approaches are currently being used to search for oral cancer biomarkers in biofluids, such as saliva and serum [15].

Bottom Line: The rationale for molecular-targeted prevention of oral cancer is promising.In addition, novel chemopreventive agents based on molecular mechanisms and targets against oral cancers will be derived from studies using appropriate animal carcinogenesis models.New approaches, such as molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy.

View Article: PubMed Central - PubMed

Affiliation: Director TCI-CaRP, 5-1-2 Minami-Uzura, Gifu City, Gifu 500-8285, Japan.

ABSTRACT
Oral cancer is one of the major global threats to public health. The development of oral cancer is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. The rationale for molecular-targeted prevention of oral cancer is promising. Biomarkers of genomic instability, including aneuploidy and allelic imbalance, are possible to measure the cancer risk of oral premalignancies. Understanding of the biology of oral carcinogenesis will yield important advances for detecting high-risk patients, monitoring preventive interventions, and assessing cancer risk and pharmacogenomics. In addition, novel chemopreventive agents based on molecular mechanisms and targets against oral cancers will be derived from studies using appropriate animal carcinogenesis models. New approaches, such as molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy.

No MeSH data available.


Related in: MedlinePlus