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Faces and eyes in human lateral prefrontal cortex.

Chan AW, Downing PE - Front Hum Neurosci (2011)

Bottom Line: Much of the work on face-selective neural activity has focused on posterior, ventral areas of the human and non-human primate brain.We examined a region at the junction of the right inferior frontal sulcus and the precentral sulcus (right inferior frontal junction or rIFJ) that responds more to faces than to several other object categories.We speculate on this role with reference to emotion perception, gaze perception, and to behavioral relevance more generally.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Wales Institute of Cognitive Neuroscience, Bangor University Gwynedd, UK.

ABSTRACT
Much of the work on face-selective neural activity has focused on posterior, ventral areas of the human and non-human primate brain. However, electrophysiological and fMRI studies have identified face responses in the prefrontal cortex. Here we used fMRI to characterize these responses in the human prefrontal cortex compared with face selectivity in posterior ventral region. We examined a region at the junction of the right inferior frontal sulcus and the precentral sulcus (right inferior frontal junction or rIFJ) that responds more to faces than to several other object categories. We find that the rIFJ and the right fusiform face area (rFFA) are broadly similar in their responses to whole faces, headless bodies, tools, and scenes. Strikingly, however, while the rFFA preferentially responds to the whole face, the rIFJ response to faces appears to be driven primarily by the eyes. This dissociation provides clues to the functional role of the rIFJ face response. We speculate on this role with reference to emotion perception, gaze perception, and to behavioral relevance more generally.

No MeSH data available.


Related in: MedlinePlus

Activation map from the 1-back task (yellow, faces–tools, p < 0. 0001, t > 5.30) overlaid onto the activation map from the eye movement localizer (green, eye movements-fixation, p < 0.0001, t > 12.0).
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Figure 5: Activation map from the 1-back task (yellow, faces–tools, p < 0. 0001, t > 5.30) overlaid onto the activation map from the eye movement localizer (green, eye movements-fixation, p < 0.0001, t > 12.0).

Mentions: A whole brain fixed-effects analysis contrasted eye movement blocks vs fixation blocks at an uncorrected threshold of p < 0.00001. The group-defined FEFs (right peak: 50, −1, 42; left peak: −48, −4, 45) and supplementary eye fields (peak: 0, −10, 66) did not overlap with rIFJ, as defined in a comparable fixed-effects group analysis (see Figure 5).


Faces and eyes in human lateral prefrontal cortex.

Chan AW, Downing PE - Front Hum Neurosci (2011)

Activation map from the 1-back task (yellow, faces–tools, p < 0. 0001, t > 5.30) overlaid onto the activation map from the eye movement localizer (green, eye movements-fixation, p < 0.0001, t > 12.0).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108382&req=5

Figure 5: Activation map from the 1-back task (yellow, faces–tools, p < 0. 0001, t > 5.30) overlaid onto the activation map from the eye movement localizer (green, eye movements-fixation, p < 0.0001, t > 12.0).
Mentions: A whole brain fixed-effects analysis contrasted eye movement blocks vs fixation blocks at an uncorrected threshold of p < 0.00001. The group-defined FEFs (right peak: 50, −1, 42; left peak: −48, −4, 45) and supplementary eye fields (peak: 0, −10, 66) did not overlap with rIFJ, as defined in a comparable fixed-effects group analysis (see Figure 5).

Bottom Line: Much of the work on face-selective neural activity has focused on posterior, ventral areas of the human and non-human primate brain.We examined a region at the junction of the right inferior frontal sulcus and the precentral sulcus (right inferior frontal junction or rIFJ) that responds more to faces than to several other object categories.We speculate on this role with reference to emotion perception, gaze perception, and to behavioral relevance more generally.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Wales Institute of Cognitive Neuroscience, Bangor University Gwynedd, UK.

ABSTRACT
Much of the work on face-selective neural activity has focused on posterior, ventral areas of the human and non-human primate brain. However, electrophysiological and fMRI studies have identified face responses in the prefrontal cortex. Here we used fMRI to characterize these responses in the human prefrontal cortex compared with face selectivity in posterior ventral region. We examined a region at the junction of the right inferior frontal sulcus and the precentral sulcus (right inferior frontal junction or rIFJ) that responds more to faces than to several other object categories. We find that the rIFJ and the right fusiform face area (rFFA) are broadly similar in their responses to whole faces, headless bodies, tools, and scenes. Strikingly, however, while the rFFA preferentially responds to the whole face, the rIFJ response to faces appears to be driven primarily by the eyes. This dissociation provides clues to the functional role of the rIFJ face response. We speculate on this role with reference to emotion perception, gaze perception, and to behavioral relevance more generally.

No MeSH data available.


Related in: MedlinePlus