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Synchronous Presence of Nasopharyngeal Carcinoma and Marginal Zone (MALT-Type) B-Cell Lymphoma in the Pharynx.

Koletsa T, Petrakis G, Karayannopoulou G, Pappas D, Markou K, Karkavelas G, Kostopoulos I - Patholog Res Int (2011)

Bottom Line: Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare.Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx.Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Medical School, Aristotle University of Thessaloniki, 54009 Thessaloniki, Greece.

ABSTRACT
Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare. Nasopharyngeal carcinoma is a nonlymphomatous, squamous cell carcinoma that occurs in the nasopharyngeal epithelium. Reported herein is a unique case of nasopharyngeal carcinoma occurring simultaneously with MALT-type lymphoma in an 83-year-old woman, who complained of deglutition dysfunction. Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx. Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms. Immunohistochemical and molecular analysis confirmed the diagnosis of nasopharyngeal carcinoma coexisting with a MALT-type lymphoma.

No MeSH data available.


Related in: MedlinePlus

EBER-positive neoplastic cells (x400).
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fig4: EBER-positive neoplastic cells (x400).

Mentions: Microscopically, neoplastic cellular nests with a reticular anastomosing pattern were observed. The neoplastic cells were oval or polygonal with round nuclei and quite often with prominent nucleoli (Figure 2). On immunohistochemical examination, these cells were positive for keratins (AE1/AE3, CK8/18, and 34βE12) (Figure 3), EMA, Cyclin D1, EGFR, and p53. Moreover, the neoplastic cells were EBER positive by ISH analysis (Figure 4).


Synchronous Presence of Nasopharyngeal Carcinoma and Marginal Zone (MALT-Type) B-Cell Lymphoma in the Pharynx.

Koletsa T, Petrakis G, Karayannopoulou G, Pappas D, Markou K, Karkavelas G, Kostopoulos I - Patholog Res Int (2011)

EBER-positive neoplastic cells (x400).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108342&req=5

fig4: EBER-positive neoplastic cells (x400).
Mentions: Microscopically, neoplastic cellular nests with a reticular anastomosing pattern were observed. The neoplastic cells were oval or polygonal with round nuclei and quite often with prominent nucleoli (Figure 2). On immunohistochemical examination, these cells were positive for keratins (AE1/AE3, CK8/18, and 34βE12) (Figure 3), EMA, Cyclin D1, EGFR, and p53. Moreover, the neoplastic cells were EBER positive by ISH analysis (Figure 4).

Bottom Line: Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare.Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx.Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Medical School, Aristotle University of Thessaloniki, 54009 Thessaloniki, Greece.

ABSTRACT
Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare. Nasopharyngeal carcinoma is a nonlymphomatous, squamous cell carcinoma that occurs in the nasopharyngeal epithelium. Reported herein is a unique case of nasopharyngeal carcinoma occurring simultaneously with MALT-type lymphoma in an 83-year-old woman, who complained of deglutition dysfunction. Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx. Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms. Immunohistochemical and molecular analysis confirmed the diagnosis of nasopharyngeal carcinoma coexisting with a MALT-type lymphoma.

No MeSH data available.


Related in: MedlinePlus