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Synchronous Presence of Nasopharyngeal Carcinoma and Marginal Zone (MALT-Type) B-Cell Lymphoma in the Pharynx.

Koletsa T, Petrakis G, Karayannopoulou G, Pappas D, Markou K, Karkavelas G, Kostopoulos I - Patholog Res Int (2011)

Bottom Line: Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare.Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx.Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Medical School, Aristotle University of Thessaloniki, 54009 Thessaloniki, Greece.

ABSTRACT
Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare. Nasopharyngeal carcinoma is a nonlymphomatous, squamous cell carcinoma that occurs in the nasopharyngeal epithelium. Reported herein is a unique case of nasopharyngeal carcinoma occurring simultaneously with MALT-type lymphoma in an 83-year-old woman, who complained of deglutition dysfunction. Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx. Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms. Immunohistochemical and molecular analysis confirmed the diagnosis of nasopharyngeal carcinoma coexisting with a MALT-type lymphoma.

No MeSH data available.


Related in: MedlinePlus

MRI image: a large soft tissue mass (arrows) invades the skull base.
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fig1: MRI image: a large soft tissue mass (arrows) invades the skull base.

Mentions: An 83-year-old Caucasian female patient presented with a six-month history of swallowing discomfort and throat pain. On nasopharyngolaryngoscopic examination, a nonulcerative submucosal tumour on the posterior pharyngeal wall was revealed. On MRI images of the head and neck area, a large soft tissue mass of nasopharynx (left and right) was noted (Figure 1), which extended to oropharynx and hypopharynx (right). The mass also invaded skull base, including foramen ovale and foramen rotundum, sphenoid sinus, both major and minor pterygium of sphenoid bone, and pterygopalatine fossa. Therefore, biopsy was taken from the posterior pharyngeal wall and was sent for pathologic examination. The patient deceased before treatment because of extensive disease, which led to respiratory failure, apnea, and heart arrest.


Synchronous Presence of Nasopharyngeal Carcinoma and Marginal Zone (MALT-Type) B-Cell Lymphoma in the Pharynx.

Koletsa T, Petrakis G, Karayannopoulou G, Pappas D, Markou K, Karkavelas G, Kostopoulos I - Patholog Res Int (2011)

MRI image: a large soft tissue mass (arrows) invades the skull base.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108342&req=5

fig1: MRI image: a large soft tissue mass (arrows) invades the skull base.
Mentions: An 83-year-old Caucasian female patient presented with a six-month history of swallowing discomfort and throat pain. On nasopharyngolaryngoscopic examination, a nonulcerative submucosal tumour on the posterior pharyngeal wall was revealed. On MRI images of the head and neck area, a large soft tissue mass of nasopharynx (left and right) was noted (Figure 1), which extended to oropharynx and hypopharynx (right). The mass also invaded skull base, including foramen ovale and foramen rotundum, sphenoid sinus, both major and minor pterygium of sphenoid bone, and pterygopalatine fossa. Therefore, biopsy was taken from the posterior pharyngeal wall and was sent for pathologic examination. The patient deceased before treatment because of extensive disease, which led to respiratory failure, apnea, and heart arrest.

Bottom Line: Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare.Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx.Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Medical School, Aristotle University of Thessaloniki, 54009 Thessaloniki, Greece.

ABSTRACT
Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare. Nasopharyngeal carcinoma is a nonlymphomatous, squamous cell carcinoma that occurs in the nasopharyngeal epithelium. Reported herein is a unique case of nasopharyngeal carcinoma occurring simultaneously with MALT-type lymphoma in an 83-year-old woman, who complained of deglutition dysfunction. Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx. Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms. Immunohistochemical and molecular analysis confirmed the diagnosis of nasopharyngeal carcinoma coexisting with a MALT-type lymphoma.

No MeSH data available.


Related in: MedlinePlus