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A historical perspective on the discovery of statins.

Endo A - Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. (2010)

Bottom Line: Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease.Over the course of nearly a century of investigation, scientists have developed several lines of evidence that establish the causal connection between blood cholesterol, atherosclerosis, and coronary heart disease.Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs--the statins--that lower cholesterol levels in blood and reduce the frequency of heart attacks.

View Article: PubMed Central - PubMed

Affiliation: Biopharm Research Laboratories, Inc., Tokyo 181-0013, Japan. aendo@biopharm.co.jp

ABSTRACT
Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease. Over the course of nearly a century of investigation, scientists have developed several lines of evidence that establish the causal connection between blood cholesterol, atherosclerosis, and coronary heart disease. Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs--the statins--that lower cholesterol levels in blood and reduce the frequency of heart attacks.

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Related in: MedlinePlus

HMG-CoA reductase reaction.
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Related In: Results  -  Collection


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fig01: HMG-CoA reductase reaction.

Mentions: The third reaction in the first stages is the committed and rate-limiting step: reduction of HMG-CoA to mevalonate is the major point of regulation on the pathway to cholesterol (Fig. 1). The major outlines of this pathway were completed by 1960, and Bloch and Lynen were awarded the Nobel Prize in 1964.


A historical perspective on the discovery of statins.

Endo A - Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. (2010)

HMG-CoA reductase reaction.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108295&req=5

fig01: HMG-CoA reductase reaction.
Mentions: The third reaction in the first stages is the committed and rate-limiting step: reduction of HMG-CoA to mevalonate is the major point of regulation on the pathway to cholesterol (Fig. 1). The major outlines of this pathway were completed by 1960, and Bloch and Lynen were awarded the Nobel Prize in 1964.

Bottom Line: Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease.Over the course of nearly a century of investigation, scientists have developed several lines of evidence that establish the causal connection between blood cholesterol, atherosclerosis, and coronary heart disease.Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs--the statins--that lower cholesterol levels in blood and reduce the frequency of heart attacks.

View Article: PubMed Central - PubMed

Affiliation: Biopharm Research Laboratories, Inc., Tokyo 181-0013, Japan. aendo@biopharm.co.jp

ABSTRACT
Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease. Over the course of nearly a century of investigation, scientists have developed several lines of evidence that establish the causal connection between blood cholesterol, atherosclerosis, and coronary heart disease. Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs--the statins--that lower cholesterol levels in blood and reduce the frequency of heart attacks.

Show MeSH
Related in: MedlinePlus