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PHQ-8 Days: a measurement option for DSM-5 Major Depressive Disorder (MDD) severity.

Dhingra SS, Kroenke K, Zack MM, Strine TW, Balluz LS - Popul Health Metr (2011)

Bottom Line: This report is based on data from the Behavioral Risk Factor Surveillance System 2006 from 198,678 survey participants who responded to all eight Patient Health Questionnaire (PHQ-8) items.In the full sample, the sensitivity and the specificity of this cut-point were 0.91 (0.90-0.93) and 0.99 (0.99-0.99), respectively.The days version of the PHQ-8 may be a valuable dimensional alternative to the traditional PHQ-8 by offering finer granularity of dimensionality (a score of 0 to 112).

View Article: PubMed Central - HTML - PubMed

Affiliation: Northrop Grumman Information Systems, CDC Programs, University Office Park/Harvard Building, 3375 Northwest Expressway, Atlanta, GA 30341, USA. SDhingra@cdc.gov.

ABSTRACT

Background: Proposed draft diagnostic criteria for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) suggest that dimensional assessments can supplement dichotomous diagnoses by incorporating measures of severity, frequency, and duration, providing the ability to monitor changes in symptoms over time and to guide appropriate treatment.

Methods: This report is based on data from the Behavioral Risk Factor Surveillance System 2006 from 198,678 survey participants who responded to all eight Patient Health Questionnaire (PHQ-8) items. We evaluated use of the days version of the PHQ-8 to determine an optimal cut-point for identifying respondents with depression and to evaluate the performance characteristics of the PHQ-8 at this cut-point.

Results: A PHQ-8 score of 55 or more days was determined to be the optimal cut-point when compared to the DSM-derived PHQ-8 algorithm for a major depressive episode (five or more symptoms present "more than half the days," at least one of which must be anhedonia or depression). In the full sample, the sensitivity and the specificity of this cut-point were 0.91 (0.90-0.93) and 0.99 (0.99-0.99), respectively.

Conclusion: The days version of the PHQ-8 may be a valuable dimensional alternative to the traditional PHQ-8 by offering finer granularity of dimensionality (a score of 0 to 112).

No MeSH data available.


Related in: MedlinePlus

Receiver Operating Characteristic (ROC) curve plotted for Sensitivity and 1 - Specificity for each number of PHQ-8 Days (0 to 112 days) in identifying respondents indicating ≥ 7 days of either anhedonia or depression (n = 22,542), with major depressive episode (MDE) as defined by a DSM-IV-derived PHQ-8 criteria of ≥ 5 symptoms present 'more than half the days' and at least one of which must be anhedonia or depression.
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Figure 1: Receiver Operating Characteristic (ROC) curve plotted for Sensitivity and 1 - Specificity for each number of PHQ-8 Days (0 to 112 days) in identifying respondents indicating ≥ 7 days of either anhedonia or depression (n = 22,542), with major depressive episode (MDE) as defined by a DSM-IV-derived PHQ-8 criteria of ≥ 5 symptoms present 'more than half the days' and at least one of which must be anhedonia or depression.

Mentions: A PHQ-8 score of 55 or more days was determined to be the optimal cut-point when compared to the DSM-derived PHQ-8 MDE algorithm (≥ five symptoms present 'more than half the days' and at least one of which must be anhedonia or depression). While the Youden's J Index was similar (0.836) over a narrow range of cut-points from 53 to 56, a cut-point of 55 or higher was selected (Table 1). AUC for the range of the test values (0-112) was 0.98 (Figure 1). Among the full sample of 198,678 people who responded to all eight PHQ-8 questions, the sensitivity and the specificity of a PHQ-8 Days cut-point of 55 or higher were 0.91 (0.90-0.93) and 0.99 (0.99-0.99), respectively.


PHQ-8 Days: a measurement option for DSM-5 Major Depressive Disorder (MDD) severity.

Dhingra SS, Kroenke K, Zack MM, Strine TW, Balluz LS - Popul Health Metr (2011)

Receiver Operating Characteristic (ROC) curve plotted for Sensitivity and 1 - Specificity for each number of PHQ-8 Days (0 to 112 days) in identifying respondents indicating ≥ 7 days of either anhedonia or depression (n = 22,542), with major depressive episode (MDE) as defined by a DSM-IV-derived PHQ-8 criteria of ≥ 5 symptoms present 'more than half the days' and at least one of which must be anhedonia or depression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108293&req=5

Figure 1: Receiver Operating Characteristic (ROC) curve plotted for Sensitivity and 1 - Specificity for each number of PHQ-8 Days (0 to 112 days) in identifying respondents indicating ≥ 7 days of either anhedonia or depression (n = 22,542), with major depressive episode (MDE) as defined by a DSM-IV-derived PHQ-8 criteria of ≥ 5 symptoms present 'more than half the days' and at least one of which must be anhedonia or depression.
Mentions: A PHQ-8 score of 55 or more days was determined to be the optimal cut-point when compared to the DSM-derived PHQ-8 MDE algorithm (≥ five symptoms present 'more than half the days' and at least one of which must be anhedonia or depression). While the Youden's J Index was similar (0.836) over a narrow range of cut-points from 53 to 56, a cut-point of 55 or higher was selected (Table 1). AUC for the range of the test values (0-112) was 0.98 (Figure 1). Among the full sample of 198,678 people who responded to all eight PHQ-8 questions, the sensitivity and the specificity of a PHQ-8 Days cut-point of 55 or higher were 0.91 (0.90-0.93) and 0.99 (0.99-0.99), respectively.

Bottom Line: This report is based on data from the Behavioral Risk Factor Surveillance System 2006 from 198,678 survey participants who responded to all eight Patient Health Questionnaire (PHQ-8) items.In the full sample, the sensitivity and the specificity of this cut-point were 0.91 (0.90-0.93) and 0.99 (0.99-0.99), respectively.The days version of the PHQ-8 may be a valuable dimensional alternative to the traditional PHQ-8 by offering finer granularity of dimensionality (a score of 0 to 112).

View Article: PubMed Central - HTML - PubMed

Affiliation: Northrop Grumman Information Systems, CDC Programs, University Office Park/Harvard Building, 3375 Northwest Expressway, Atlanta, GA 30341, USA. SDhingra@cdc.gov.

ABSTRACT

Background: Proposed draft diagnostic criteria for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) suggest that dimensional assessments can supplement dichotomous diagnoses by incorporating measures of severity, frequency, and duration, providing the ability to monitor changes in symptoms over time and to guide appropriate treatment.

Methods: This report is based on data from the Behavioral Risk Factor Surveillance System 2006 from 198,678 survey participants who responded to all eight Patient Health Questionnaire (PHQ-8) items. We evaluated use of the days version of the PHQ-8 to determine an optimal cut-point for identifying respondents with depression and to evaluate the performance characteristics of the PHQ-8 at this cut-point.

Results: A PHQ-8 score of 55 or more days was determined to be the optimal cut-point when compared to the DSM-derived PHQ-8 algorithm for a major depressive episode (five or more symptoms present "more than half the days," at least one of which must be anhedonia or depression). In the full sample, the sensitivity and the specificity of this cut-point were 0.91 (0.90-0.93) and 0.99 (0.99-0.99), respectively.

Conclusion: The days version of the PHQ-8 may be a valuable dimensional alternative to the traditional PHQ-8 by offering finer granularity of dimensionality (a score of 0 to 112).

No MeSH data available.


Related in: MedlinePlus