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Imaging of melanoma: usefulness of ultrasonography before and after contrast injection for diagnosis and early evaluation of treatment.

Chami L, Lassau N, Chebil M, Robert C - Clin Cosmet Investig Dermatol (2011)

Bottom Line: Some morphological criteria (strong delineation, hypoechoic texture, homogeneity) have been reported to help differentiate between malignant and benign pigmented blue lesions, but remain insufficient.Vascular ultrasound analysis using Doppler mode provides additional information and showed good specificity for malignancy (90%-100%), but variable sensitivity (34%-100%).Recent advances in ultrasound imaging allow functional evaluation.

View Article: PubMed Central - PubMed

Affiliation: Imaging Department Institut Gustave Roussy, Villejuif, France;

ABSTRACT
High-frequency ultrasound (8-14 MHz) is routinely used to display cutaneous melanomas. Maximum thickness measurement (Breslow index) has been shown to be well correlated to histologic findings for lesions of more than 0.75 mm. Some morphological criteria (strong delineation, hypoechoic texture, homogeneity) have been reported to help differentiate between malignant and benign pigmented blue lesions, but remain insufficient. Vascular ultrasound analysis using Doppler mode provides additional information and showed good specificity for malignancy (90%-100%), but variable sensitivity (34%-100%). Recent advances in ultrasound imaging allow functional evaluation. Likewise, dynamic contrast-enhanced ultrasound using contrast medium injection and specific perfusion and quantification software showed promising results in clinical and preclinical trials for early prediction of tumor response to target treatments.

No MeSH data available.


Related in: MedlinePlus

In transit melanoma metastasis treated by isolated limb perfusion in a good responder. Ultrasound B mode (gray scale) scanning of superficial subcutaneous hypoechoic nodule of the right limb. A) Before treatment, the lesion was 14.8 mm in size. B) At day 1 after treatment no significant morphologic change was observed (14.2 mm). C) At day 7, the lesion shows a significant decrease in size (8.3 mm). D) In the same patient, after modelling, perfusion curves expressed as linear raw data show an important increase in perfusion parameters at day 1 after treatment compared with baseline.
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f2-ccid-4-001: In transit melanoma metastasis treated by isolated limb perfusion in a good responder. Ultrasound B mode (gray scale) scanning of superficial subcutaneous hypoechoic nodule of the right limb. A) Before treatment, the lesion was 14.8 mm in size. B) At day 1 after treatment no significant morphologic change was observed (14.2 mm). C) At day 7, the lesion shows a significant decrease in size (8.3 mm). D) In the same patient, after modelling, perfusion curves expressed as linear raw data show an important increase in perfusion parameters at day 1 after treatment compared with baseline.

Mentions: An animal study evaluating the early disruptive effects of AVE 8062 on tumor vasculature showed that perfusion parameters variations extracted from linear raw data were well correlated with microvascular density changes. These were more accurate than power Doppler or visual evaluation from video data.36,37 Likewise, in an initial clinical study involving 50 patients with in transit melanoma metastasis and treated with isolated limb perfusion, quantification showed that initial changes (day 1 after treatment) in some perfusion parameters (maximum intensity, slope, wash-out area, time to peak) were significantly modified in responders38 (Figure 2).


Imaging of melanoma: usefulness of ultrasonography before and after contrast injection for diagnosis and early evaluation of treatment.

Chami L, Lassau N, Chebil M, Robert C - Clin Cosmet Investig Dermatol (2011)

In transit melanoma metastasis treated by isolated limb perfusion in a good responder. Ultrasound B mode (gray scale) scanning of superficial subcutaneous hypoechoic nodule of the right limb. A) Before treatment, the lesion was 14.8 mm in size. B) At day 1 after treatment no significant morphologic change was observed (14.2 mm). C) At day 7, the lesion shows a significant decrease in size (8.3 mm). D) In the same patient, after modelling, perfusion curves expressed as linear raw data show an important increase in perfusion parameters at day 1 after treatment compared with baseline.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3108283&req=5

f2-ccid-4-001: In transit melanoma metastasis treated by isolated limb perfusion in a good responder. Ultrasound B mode (gray scale) scanning of superficial subcutaneous hypoechoic nodule of the right limb. A) Before treatment, the lesion was 14.8 mm in size. B) At day 1 after treatment no significant morphologic change was observed (14.2 mm). C) At day 7, the lesion shows a significant decrease in size (8.3 mm). D) In the same patient, after modelling, perfusion curves expressed as linear raw data show an important increase in perfusion parameters at day 1 after treatment compared with baseline.
Mentions: An animal study evaluating the early disruptive effects of AVE 8062 on tumor vasculature showed that perfusion parameters variations extracted from linear raw data were well correlated with microvascular density changes. These were more accurate than power Doppler or visual evaluation from video data.36,37 Likewise, in an initial clinical study involving 50 patients with in transit melanoma metastasis and treated with isolated limb perfusion, quantification showed that initial changes (day 1 after treatment) in some perfusion parameters (maximum intensity, slope, wash-out area, time to peak) were significantly modified in responders38 (Figure 2).

Bottom Line: Some morphological criteria (strong delineation, hypoechoic texture, homogeneity) have been reported to help differentiate between malignant and benign pigmented blue lesions, but remain insufficient.Vascular ultrasound analysis using Doppler mode provides additional information and showed good specificity for malignancy (90%-100%), but variable sensitivity (34%-100%).Recent advances in ultrasound imaging allow functional evaluation.

View Article: PubMed Central - PubMed

Affiliation: Imaging Department Institut Gustave Roussy, Villejuif, France;

ABSTRACT
High-frequency ultrasound (8-14 MHz) is routinely used to display cutaneous melanomas. Maximum thickness measurement (Breslow index) has been shown to be well correlated to histologic findings for lesions of more than 0.75 mm. Some morphological criteria (strong delineation, hypoechoic texture, homogeneity) have been reported to help differentiate between malignant and benign pigmented blue lesions, but remain insufficient. Vascular ultrasound analysis using Doppler mode provides additional information and showed good specificity for malignancy (90%-100%), but variable sensitivity (34%-100%). Recent advances in ultrasound imaging allow functional evaluation. Likewise, dynamic contrast-enhanced ultrasound using contrast medium injection and specific perfusion and quantification software showed promising results in clinical and preclinical trials for early prediction of tumor response to target treatments.

No MeSH data available.


Related in: MedlinePlus