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Whole genome analysis of infectious bovine keratoconjunctivitis in Angus cattle using Bayesian threshold models.

Kizilkaya K, Tait RG, Garrick DJ, Fernando RL, Reecy JM - BMC Proc (2011)

Bottom Line: Bayes-C threshold models were used to estimate SNP effects by classifying IBK into two, three or nine ordered categories.Magnitudes of genetic variances estimated in localized regions across the genome indicated that SNP within the most informative regions accounted for much of the genetic variance of IBK and pointed out some degree of association to IBK.There are many candidate genes in these regions which could include a gene or group of genes associated with bacterial disease in cattle.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Animal Science, Iowa State University, Ames, IA 50011 USA. jreecy@iastate.edu.

ABSTRACT
Infectious bovine keratoconjunctivitis (IBK), also known as pinkeye, is characterized by damage to the cornea and is an economically important, lowly heritable, categorical disease trait in beef cattle. Scores of eye damage were collected at weaning on 858 Angus cattle. SNP genotypes for each animal were obtained from BovineSNP50 Infinium-beadchips. Simultaneous associations of all SNP with IBK phenotype were determined using Bayes-C that treats SNP effects as random with equal variance for an assumed fraction (π=0.999) of SNP having no effect on IBK scores. Bayes-C threshold models were used to estimate SNP effects by classifying IBK into two, three or nine ordered categories. Magnitudes of genetic variances estimated in localized regions across the genome indicated that SNP within the most informative regions accounted for much of the genetic variance of IBK and pointed out some degree of association to IBK. There are many candidate genes in these regions which could include a gene or group of genes associated with bacterial disease in cattle.

No MeSH data available.


Related in: MedlinePlus

Illustration of the criteria used to assign severity scores to affected eyes. Score 1= ocular lesion covering less than 1/3 of the cornea; Score 2= ocular lesion covering 1/3 - 2/3 of the cornea; Score 3= ocular lesion covering more than 2/3 of the cornea
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Figure 1: Illustration of the criteria used to assign severity scores to affected eyes. Score 1= ocular lesion covering less than 1/3 of the cornea; Score 2= ocular lesion covering 1/3 - 2/3 of the cornea; Score 3= ocular lesion covering more than 2/3 of the cornea

Mentions: Infectious bovine keratoconjunctivitis records were collected from 858 animals born and raised in the Iowa State University Angus research herd. Both eyes were scored individually. The IBK scoring system for one eye used a scale from 0 to 4. A score of 0 denotes a cornea with no apparent lesions, 1 for a cornea with a lesion covering less than 1/3 of the cornea, 2 for a lesion covering 1/3 to 2/3 of the cornea, 3 for a lesion covering more than 2/3 of the cornea, and 4 for perforation of the cornea (Figure 1) [4].


Whole genome analysis of infectious bovine keratoconjunctivitis in Angus cattle using Bayesian threshold models.

Kizilkaya K, Tait RG, Garrick DJ, Fernando RL, Reecy JM - BMC Proc (2011)

Illustration of the criteria used to assign severity scores to affected eyes. Score 1= ocular lesion covering less than 1/3 of the cornea; Score 2= ocular lesion covering 1/3 - 2/3 of the cornea; Score 3= ocular lesion covering more than 2/3 of the cornea
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108217&req=5

Figure 1: Illustration of the criteria used to assign severity scores to affected eyes. Score 1= ocular lesion covering less than 1/3 of the cornea; Score 2= ocular lesion covering 1/3 - 2/3 of the cornea; Score 3= ocular lesion covering more than 2/3 of the cornea
Mentions: Infectious bovine keratoconjunctivitis records were collected from 858 animals born and raised in the Iowa State University Angus research herd. Both eyes were scored individually. The IBK scoring system for one eye used a scale from 0 to 4. A score of 0 denotes a cornea with no apparent lesions, 1 for a cornea with a lesion covering less than 1/3 of the cornea, 2 for a lesion covering 1/3 to 2/3 of the cornea, 3 for a lesion covering more than 2/3 of the cornea, and 4 for perforation of the cornea (Figure 1) [4].

Bottom Line: Bayes-C threshold models were used to estimate SNP effects by classifying IBK into two, three or nine ordered categories.Magnitudes of genetic variances estimated in localized regions across the genome indicated that SNP within the most informative regions accounted for much of the genetic variance of IBK and pointed out some degree of association to IBK.There are many candidate genes in these regions which could include a gene or group of genes associated with bacterial disease in cattle.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Animal Science, Iowa State University, Ames, IA 50011 USA. jreecy@iastate.edu.

ABSTRACT
Infectious bovine keratoconjunctivitis (IBK), also known as pinkeye, is characterized by damage to the cornea and is an economically important, lowly heritable, categorical disease trait in beef cattle. Scores of eye damage were collected at weaning on 858 Angus cattle. SNP genotypes for each animal were obtained from BovineSNP50 Infinium-beadchips. Simultaneous associations of all SNP with IBK phenotype were determined using Bayes-C that treats SNP effects as random with equal variance for an assumed fraction (π=0.999) of SNP having no effect on IBK scores. Bayes-C threshold models were used to estimate SNP effects by classifying IBK into two, three or nine ordered categories. Magnitudes of genetic variances estimated in localized regions across the genome indicated that SNP within the most informative regions accounted for much of the genetic variance of IBK and pointed out some degree of association to IBK. There are many candidate genes in these regions which could include a gene or group of genes associated with bacterial disease in cattle.

No MeSH data available.


Related in: MedlinePlus