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Heavy drinking is associated with poor blood pressure control in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

Judd SE, McClure LA, Howard VJ, Lackland DT, Halanych JH, Kabagambe EK - Int J Environ Res Public Health (2011)

Bottom Line: Diabetes and gender significantly modified (interaction P < 0.05 for both) the association between alcohol use and hypertension, although heavy drinking remained associated with increased odds of hypertension in sub-group analyses.We did not observe the previously described J-shaped relationship in any sub-group except white females.These data suggest heavy alcohol consumption is associated with poor BP control and that heavy drinkers may want to consider limiting alcohol intake in order to manage hypertension.

View Article: PubMed Central - PubMed

Affiliation: Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA. sejudd@uab.edu

ABSTRACT
Alcohol intake has been shown to have a J-shaped association with blood pressure (BP). However, this association has not been examined in mixed race populations or in people with diabetes where tighter blood pressure control is recommended. Participants in the REGARDS study who were 45 years or older (n = 30,239) were included. Medical history (including self-reported alcohol intake) was collected by telephone while blood collection and clinical measurements were done during an in-home visit. We defined diabetes as use of medications and/or fasting glucose ≥ 126 mg/dL and hypertension as use of blood pressure lowering medications and/or BP ≥ 140/90 mmHg or BP ≥ 130/80 mmHg in people with diabetes. After adjustment for confounders, heavy drinking was associated with an increased odds of hypertension (OR = 1.59; 95% CI = 1.37, 1.87). Diabetes and gender significantly modified (interaction P < 0.05 for both) the association between alcohol use and hypertension, although heavy drinking remained associated with increased odds of hypertension in sub-group analyses. We did not observe the previously described J-shaped relationship in any sub-group except white females. These data suggest heavy alcohol consumption is associated with poor BP control and that heavy drinkers may want to consider limiting alcohol intake in order to manage hypertension.

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Related in: MedlinePlus

Forest plot exploring interactions between diabetes, race, and sex and alcohol intake on the odds of having hypertension in the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study participants. Non-drinkers are the referent group. Diabetes was a significant effect modifier (P for interaction = 0.02), while race was marginally non-significant (P for interaction = 0.10) and gender was highly significant (P for interaction < 0.001). The fully adjusted model controlled for age, race, sex, region of residence, income, education, smoking status, physical activity, BMI, HDL, LDL, CRP, diabetes, and history of stroke, and heart disease. Values in the figure are odds ratios and corresponding 95% CIs.
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f1-ijerph-08-01601: Forest plot exploring interactions between diabetes, race, and sex and alcohol intake on the odds of having hypertension in the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study participants. Non-drinkers are the referent group. Diabetes was a significant effect modifier (P for interaction = 0.02), while race was marginally non-significant (P for interaction = 0.10) and gender was highly significant (P for interaction < 0.001). The fully adjusted model controlled for age, race, sex, region of residence, income, education, smoking status, physical activity, BMI, HDL, LDL, CRP, diabetes, and history of stroke, and heart disease. Values in the figure are odds ratios and corresponding 95% CIs.


Heavy drinking is associated with poor blood pressure control in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

Judd SE, McClure LA, Howard VJ, Lackland DT, Halanych JH, Kabagambe EK - Int J Environ Res Public Health (2011)

Forest plot exploring interactions between diabetes, race, and sex and alcohol intake on the odds of having hypertension in the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study participants. Non-drinkers are the referent group. Diabetes was a significant effect modifier (P for interaction = 0.02), while race was marginally non-significant (P for interaction = 0.10) and gender was highly significant (P for interaction < 0.001). The fully adjusted model controlled for age, race, sex, region of residence, income, education, smoking status, physical activity, BMI, HDL, LDL, CRP, diabetes, and history of stroke, and heart disease. Values in the figure are odds ratios and corresponding 95% CIs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3108130&req=5

f1-ijerph-08-01601: Forest plot exploring interactions between diabetes, race, and sex and alcohol intake on the odds of having hypertension in the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study participants. Non-drinkers are the referent group. Diabetes was a significant effect modifier (P for interaction = 0.02), while race was marginally non-significant (P for interaction = 0.10) and gender was highly significant (P for interaction < 0.001). The fully adjusted model controlled for age, race, sex, region of residence, income, education, smoking status, physical activity, BMI, HDL, LDL, CRP, diabetes, and history of stroke, and heart disease. Values in the figure are odds ratios and corresponding 95% CIs.
Bottom Line: Diabetes and gender significantly modified (interaction P < 0.05 for both) the association between alcohol use and hypertension, although heavy drinking remained associated with increased odds of hypertension in sub-group analyses.We did not observe the previously described J-shaped relationship in any sub-group except white females.These data suggest heavy alcohol consumption is associated with poor BP control and that heavy drinkers may want to consider limiting alcohol intake in order to manage hypertension.

View Article: PubMed Central - PubMed

Affiliation: Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA. sejudd@uab.edu

ABSTRACT
Alcohol intake has been shown to have a J-shaped association with blood pressure (BP). However, this association has not been examined in mixed race populations or in people with diabetes where tighter blood pressure control is recommended. Participants in the REGARDS study who were 45 years or older (n = 30,239) were included. Medical history (including self-reported alcohol intake) was collected by telephone while blood collection and clinical measurements were done during an in-home visit. We defined diabetes as use of medications and/or fasting glucose ≥ 126 mg/dL and hypertension as use of blood pressure lowering medications and/or BP ≥ 140/90 mmHg or BP ≥ 130/80 mmHg in people with diabetes. After adjustment for confounders, heavy drinking was associated with an increased odds of hypertension (OR = 1.59; 95% CI = 1.37, 1.87). Diabetes and gender significantly modified (interaction P < 0.05 for both) the association between alcohol use and hypertension, although heavy drinking remained associated with increased odds of hypertension in sub-group analyses. We did not observe the previously described J-shaped relationship in any sub-group except white females. These data suggest heavy alcohol consumption is associated with poor BP control and that heavy drinkers may want to consider limiting alcohol intake in order to manage hypertension.

Show MeSH
Related in: MedlinePlus