Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis.
Bottom Line: In our multicentre cohort study and cost-effectiveness analysis we analysed demographic and test results from three centres in the UK (from 2008 to 2010) that used interferon-γ release-assay (IGRA) to screen immigrants aged 35 years or younger for latent tuberculosis infection.Positive results were independently associated with increases in tuberculosis incidence in immigrants' countries of origin (p=0·0006), male sex (p = 0·046), and age (p < 0·0001).Medical Research Council and Wellcome Trust.
Affiliation: Department of Infectious Disease Epidemiology, Imperial College London, London, UK.Show MeSH
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Mentions: IGRA results were available for all participants. Overall, 245 individuals tested positive (20%, 95% CI 18–22%), 982 were negative (80%, 77–82%), and two had indeterminate results (<1%, 0–1%). Participants attending the Westminster centre had a significantly lower proportion of IGRA-positive results than did those attending the Leeds and Blackburn centres (p=0·02). The proportions of positive immigrants aged less than 16 years, 16–25 years, and 26–35 years were 19%, 15%, and 25%, respectively. In multivariate analysis, male sex, increasing age, and tuberculosis incidence in country of origin were associated with positive IGRA (table 1, figure 2).
Affiliation: Department of Infectious Disease Epidemiology, Imperial College London, London, UK.