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Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis.

Pareek M, Watson JP, Ormerod LP, Kon OM, Woltmann G, White PJ, Abubakar I, Lalvani A - Lancet Infect Dis (2011)

Bottom Line: In our multicentre cohort study and cost-effectiveness analysis we analysed demographic and test results from three centres in the UK (from 2008 to 2010) that used interferon-γ release-assay (IGRA) to screen immigrants aged 35 years or younger for latent tuberculosis infection.Positive results were independently associated with increases in tuberculosis incidence in immigrants' countries of origin (p=0·0006), male sex (p = 0·046), and age (p < 0·0001).Medical Research Council and Wellcome Trust.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

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Proportion of immigrants aged 35 years or younger who tested IGRA positive according to tuberculosis incidence in their country of originIGRA=interferon-γ release assays. Bars=95% CIs.
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fig2: Proportion of immigrants aged 35 years or younger who tested IGRA positive according to tuberculosis incidence in their country of originIGRA=interferon-γ release assays. Bars=95% CIs.

Mentions: IGRA results were available for all participants. Overall, 245 individuals tested positive (20%, 95% CI 18–22%), 982 were negative (80%, 77–82%), and two had indeterminate results (<1%, 0–1%). Participants attending the Westminster centre had a significantly lower proportion of IGRA-positive results than did those attending the Leeds and Blackburn centres (p=0·02). The proportions of positive immigrants aged less than 16 years, 16–25 years, and 26–35 years were 19%, 15%, and 25%, respectively. In multivariate analysis, male sex, increasing age, and tuberculosis incidence in country of origin were associated with positive IGRA (table 1, figure 2).


Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis.

Pareek M, Watson JP, Ormerod LP, Kon OM, Woltmann G, White PJ, Abubakar I, Lalvani A - Lancet Infect Dis (2011)

Proportion of immigrants aged 35 years or younger who tested IGRA positive according to tuberculosis incidence in their country of originIGRA=interferon-γ release assays. Bars=95% CIs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108102&req=5

fig2: Proportion of immigrants aged 35 years or younger who tested IGRA positive according to tuberculosis incidence in their country of originIGRA=interferon-γ release assays. Bars=95% CIs.
Mentions: IGRA results were available for all participants. Overall, 245 individuals tested positive (20%, 95% CI 18–22%), 982 were negative (80%, 77–82%), and two had indeterminate results (<1%, 0–1%). Participants attending the Westminster centre had a significantly lower proportion of IGRA-positive results than did those attending the Leeds and Blackburn centres (p=0·02). The proportions of positive immigrants aged less than 16 years, 16–25 years, and 26–35 years were 19%, 15%, and 25%, respectively. In multivariate analysis, male sex, increasing age, and tuberculosis incidence in country of origin were associated with positive IGRA (table 1, figure 2).

Bottom Line: In our multicentre cohort study and cost-effectiveness analysis we analysed demographic and test results from three centres in the UK (from 2008 to 2010) that used interferon-γ release-assay (IGRA) to screen immigrants aged 35 years or younger for latent tuberculosis infection.Positive results were independently associated with increases in tuberculosis incidence in immigrants' countries of origin (p=0·0006), male sex (p = 0·046), and age (p < 0·0001).Medical Research Council and Wellcome Trust.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

Show MeSH
Related in: MedlinePlus