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Carcinoma of gall bladder presenting as dermatomyositis.

Narasimhaiah DA, Premkumar JA, Moses V, Chacko G - Ann Indian Acad Neurol (2011)

Bottom Line: Dermatomyositis (DM) is a type of inflammatory myopathy that is strongly associated with a broad range of malignant disorders.The malignancies most commonly associated with DM are carcinomas of ovary, lung, stomach, colorectal and pancreas, as well as non-Hodgkin's lymphoma.An association of DM with carcinoma of the gall bladder (GB) is extremely rare with only two previously reported cases in the literature.

View Article: PubMed Central - PubMed

Affiliation: Department of General Pathology, Christian Medical College, Vellore- 632004, Tamil Nadu, India.

ABSTRACT
Cancer-related muscle diseases are usually paraneoplastic disorders. Dermatomyositis (DM) is a type of inflammatory myopathy that is strongly associated with a broad range of malignant disorders. The malignancy can occur before, concomitantly or after the onset of myositis. The malignancies most commonly associated with DM are carcinomas of ovary, lung, stomach, colorectal and pancreas, as well as non-Hodgkin's lymphoma. An association of DM with carcinoma of the gall bladder (GB) is extremely rare with only two previously reported cases in the literature. We report a case of carcinoma of GB with DM as the paraneoplastic manifestation.

No MeSH data available.


Related in: MedlinePlus

Vastus lateralis showing myopathic features (H and E, ×100)
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Figure 0001: Vastus lateralis showing myopathic features (H and E, ×100)

Mentions: A biopsy from the right vastus lateralis showed myopathic features with fiber size variation, myophagocytosis and regenerative activity [Figure 1]. There was myofiber necrosis, perifascicular atrophy [Figure 2] and patchy endomysial infiltrate of lymphocytes. Occasional endomysial capillaries showed deposits of membrane attack complex of complement. The morphologic features were consistent with DM.


Carcinoma of gall bladder presenting as dermatomyositis.

Narasimhaiah DA, Premkumar JA, Moses V, Chacko G - Ann Indian Acad Neurol (2011)

Vastus lateralis showing myopathic features (H and E, ×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108078&req=5

Figure 0001: Vastus lateralis showing myopathic features (H and E, ×100)
Mentions: A biopsy from the right vastus lateralis showed myopathic features with fiber size variation, myophagocytosis and regenerative activity [Figure 1]. There was myofiber necrosis, perifascicular atrophy [Figure 2] and patchy endomysial infiltrate of lymphocytes. Occasional endomysial capillaries showed deposits of membrane attack complex of complement. The morphologic features were consistent with DM.

Bottom Line: Dermatomyositis (DM) is a type of inflammatory myopathy that is strongly associated with a broad range of malignant disorders.The malignancies most commonly associated with DM are carcinomas of ovary, lung, stomach, colorectal and pancreas, as well as non-Hodgkin's lymphoma.An association of DM with carcinoma of the gall bladder (GB) is extremely rare with only two previously reported cases in the literature.

View Article: PubMed Central - PubMed

Affiliation: Department of General Pathology, Christian Medical College, Vellore- 632004, Tamil Nadu, India.

ABSTRACT
Cancer-related muscle diseases are usually paraneoplastic disorders. Dermatomyositis (DM) is a type of inflammatory myopathy that is strongly associated with a broad range of malignant disorders. The malignancy can occur before, concomitantly or after the onset of myositis. The malignancies most commonly associated with DM are carcinomas of ovary, lung, stomach, colorectal and pancreas, as well as non-Hodgkin's lymphoma. An association of DM with carcinoma of the gall bladder (GB) is extremely rare with only two previously reported cases in the literature. We report a case of carcinoma of GB with DM as the paraneoplastic manifestation.

No MeSH data available.


Related in: MedlinePlus