Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions.
Bottom Line: Constitutive phosphorylation of SakA induced by the fungicide fludioxonil prevents both, germ tube formation and nuclear division.Similarly, Neurospora crassa SakA orthologue OS-2 is phosphorylated in intact conidia and gets dephosphorylated during germination.We propose that SakA-AtfA interaction regulates gene expression during stress and conidiophore development and that SAPK phosphorylation is a conserved mechanism to regulate transitions between non-growing (spore) and growing (mycelia) states.
Affiliation: Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-242, 04510, México, D.F., México.Show MeSH
Related in: MedlinePlus
Mentions: Since the inactivation of sakA causes a derepression of sexual development (Kawasaki et al., 2002; Lara-Ortiz et al., 2003), we followed the development of sexual fruiting bodies (cleistothecia) in the ΔatfA mutant. As shown in Fig. 3A and B, the elimination of atfA also resulted in derepressed sexual development and higher numbers of cleistothecia, suggesting that SakA and AtfA repress sexual development through the same pathway.
Affiliation: Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-242, 04510, México, D.F., México.