Limits...
How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?

Montironi R, Cheng L, Scarpelli M, Mazzucchelli R, Lopez-Beltran A - Diagn Pathol (2011)

Bottom Line: The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary.This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

View Article: PubMed Central - HTML - PubMed

Affiliation: Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region (Ancona), Ancona, Italy. r.montironi@univpm.it

ABSTRACT
The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary. This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

Show MeSH

Related in: MedlinePlus

Low-grade papillary urothelial carcinoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3107770&req=5

Figure 8: Low-grade papillary urothelial carcinoma.

Mentions: This category contains the intermediate group of lesions. In the 1973 WHO system this would include the lower 1/2 of grade 2 papillary carcinoma. Histologically the papillae are largely delicate and separate but some fusion may be seen. At low magnification there is a generally ordered appearance to the cells within the epithelium (Figure 8). The nuclei tend to be uniformly enlarged and retain the elongated to oval shape of normal urothelial cells. The chromatin remains fine with small and generally inconspicuous nucleoli. Mitoses may be present but are few and remain basally located. The urothelium lining the papillae is similar to flat dysplasia. These tumors have a significantly higher recurrence rate than for PUNLMP and similar to high-grade papillary carcinomas. They also have a significantly higher rate of stage progression than PUNLMP but significantly lower than for high-grade papillary carcinoma [2,5,9]. A review of the literature revealed a mean recurrence rate of 50% and mean stage progression rate of 10% [5,8].


How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?

Montironi R, Cheng L, Scarpelli M, Mazzucchelli R, Lopez-Beltran A - Diagn Pathol (2011)

Low-grade papillary urothelial carcinoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3107770&req=5

Figure 8: Low-grade papillary urothelial carcinoma.
Mentions: This category contains the intermediate group of lesions. In the 1973 WHO system this would include the lower 1/2 of grade 2 papillary carcinoma. Histologically the papillae are largely delicate and separate but some fusion may be seen. At low magnification there is a generally ordered appearance to the cells within the epithelium (Figure 8). The nuclei tend to be uniformly enlarged and retain the elongated to oval shape of normal urothelial cells. The chromatin remains fine with small and generally inconspicuous nucleoli. Mitoses may be present but are few and remain basally located. The urothelium lining the papillae is similar to flat dysplasia. These tumors have a significantly higher recurrence rate than for PUNLMP and similar to high-grade papillary carcinomas. They also have a significantly higher rate of stage progression than PUNLMP but significantly lower than for high-grade papillary carcinoma [2,5,9]. A review of the literature revealed a mean recurrence rate of 50% and mean stage progression rate of 10% [5,8].

Bottom Line: The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary.This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

View Article: PubMed Central - HTML - PubMed

Affiliation: Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region (Ancona), Ancona, Italy. r.montironi@univpm.it

ABSTRACT
The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary. This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

Show MeSH
Related in: MedlinePlus