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How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?

Montironi R, Cheng L, Scarpelli M, Mazzucchelli R, Lopez-Beltran A - Diagn Pathol (2011)

Bottom Line: The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary.This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

View Article: PubMed Central - HTML - PubMed

Affiliation: Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region (Ancona), Ancona, Italy. r.montironi@univpm.it

ABSTRACT
The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary. This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

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Related in: MedlinePlus

Urothelial carcinoma with lamina propria invasion.
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Figure 12: Urothelial carcinoma with lamina propria invasion.

Mentions: The invasive front of the tumour may be seen as single cells or nests or finger-like extensions (Figure 12) [9]. The infiltrating component often shows higher degree of nuclear pleomorphism and has abundant eosinophilic cytoplasm. Stroma may show a desmoplastic or heavy inflammatory response. Retraction artifacts, mimicking vascular-lymphatic invasion, are particularly frequent in tumours superficially invading into the lamina propria and should not be overdiagnosed as vascular invasion. Vascular invasion in cases with lamina propria invasion is uncommon and should be diagnosed only in unequivocal cases or after immunohistochemistry [14]. In the absence of stromal response the diagnosis of invasion rely on the characteristics of the infiltrating epithelium.


How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?

Montironi R, Cheng L, Scarpelli M, Mazzucchelli R, Lopez-Beltran A - Diagn Pathol (2011)

Urothelial carcinoma with lamina propria invasion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3107770&req=5

Figure 12: Urothelial carcinoma with lamina propria invasion.
Mentions: The invasive front of the tumour may be seen as single cells or nests or finger-like extensions (Figure 12) [9]. The infiltrating component often shows higher degree of nuclear pleomorphism and has abundant eosinophilic cytoplasm. Stroma may show a desmoplastic or heavy inflammatory response. Retraction artifacts, mimicking vascular-lymphatic invasion, are particularly frequent in tumours superficially invading into the lamina propria and should not be overdiagnosed as vascular invasion. Vascular invasion in cases with lamina propria invasion is uncommon and should be diagnosed only in unequivocal cases or after immunohistochemistry [14]. In the absence of stromal response the diagnosis of invasion rely on the characteristics of the infiltrating epithelium.

Bottom Line: The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary.This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

View Article: PubMed Central - HTML - PubMed

Affiliation: Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region (Ancona), Ancona, Italy. r.montironi@univpm.it

ABSTRACT
The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary. This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists.

Show MeSH
Related in: MedlinePlus