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A population-based survey of Chronic REnal Disease In Turkey--the CREDIT study.

Süleymanlar G, Utaş C, Arinsoy T, Ateş K, Altun B, Altiparmak MR, Ecder T, Yilmaz ME, Çamsari T, Başçi A, Odabas AR, Serdengeçti K - Nephrol. Dial. Transplant. (2010)

Bottom Line: The overall prevalence of CKD was 15.7%; it was higher in women than men (18.4% vs. 12.8%, P < 0.001) and increased with increasing age of the subjects.The prevalence of hypertension (32.7% in the general population), diabetes (12.7%), dyslipidaemia (76.3%), obesity (20.1%) and metabolic syndrome (31.3%) was significantly higher in subjects with CKD than subjects without CKD (P < 0.001 for all).The prevalence of CKD in Turkey is 15.7%.

View Article: PubMed Central - PubMed

Affiliation: Nephrology Division, Department of Medicine, Akdeniz University Medical School, Antalya, Turkey. gulteksu@superonline.com

ABSTRACT

Background: Chronic kidney disease (CKD) is a growing health problem worldwide that leads to end-stage kidney failure and cardiovascular complications. We aimed to determine the prevalence of CKD in Turkey, and to evaluate relationships between CKD and cardiovascular risk factors in a population-based survey.

Methods: Medical data were collected through home visits and interviews. Serum creatinine, blood glucose, total cholesterol, triglycerides, HDL, LDL and uric acid were determined from 12-h fasting blood samples, and spot urine tests were performed for subjects who gave consent to laboratory evaluation.

Results: A total of 10 872 participants were included in the study. The final analysis was performed on 10 748 subjects (mean age 40.5 ± 16.3 years; 55.7% women) and excluded 124 pregnant women. A low glomerular filtration rate (GFR) (< 60 mL/min/1.73 m(2)) was present in 5.2% of the subjects who were evaluated for GFR, while microalbuminuria and macroalbuminuria were observed in 10.2% and 2% of the subjects, respectively. The presence of CKD was assessed in subjects who gave consent for urinary albumin excretion measurement (n = 8765). The overall prevalence of CKD was 15.7%; it was higher in women than men (18.4% vs. 12.8%, P < 0.001) and increased with increasing age of the subjects. The prevalence of hypertension (32.7% in the general population), diabetes (12.7%), dyslipidaemia (76.3%), obesity (20.1%) and metabolic syndrome (31.3%) was significantly higher in subjects with CKD than subjects without CKD (P < 0.001 for all).

Conclusions: The prevalence of CKD in Turkey is 15.7%. Cardiovascular risk factors were significantly more prevalent in CKD patients.

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Related in: MedlinePlus

Glomerular filtration rate (A), and microalbuminuria [as microalbuminuria (30–299 mg/g creatinine) or macroalbuminuria (> 300 mg/g creatinine)] (B) in subjects with and without concomitant hypertension, diabetes mellitus, dyslipidaemia, obesity or metabolic syndrome.
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fig4: Glomerular filtration rate (A), and microalbuminuria [as microalbuminuria (30–299 mg/g creatinine) or macroalbuminuria (> 300 mg/g creatinine)] (B) in subjects with and without concomitant hypertension, diabetes mellitus, dyslipidaemia, obesity or metabolic syndrome.

Mentions: Mean values of kidney function and/or damage indicators, such as serum creatinine, GFR and microalbuminuria, in subjects with and without hypertension, diabetes, dyslipidaemia, obesity and metabolic syndrome also demonstrated that renal function in subjects with cardiovascular risk factors was significantly impaired compared with healthy individuals (Table 5). The prevalence of decreased GFR and microalbuminuria was higher in subjects having these risk factors, particularly in those having hypertension and diabetes (Figure 4). The prevalence of CKD among subjects with and without hypertension was 25.3% and 10.6%, respectively [P < 0.001, odds ratio 1.58 (95% CI: 1.48–1.68)]. Similarly, CKD was significantly more common in subjects with diabetes than in subjects without diabetes [32.4% vs. 13%; P < 0.001, odds ratio 1.22 (95% CI: 1.18–1.27)].


A population-based survey of Chronic REnal Disease In Turkey--the CREDIT study.

Süleymanlar G, Utaş C, Arinsoy T, Ateş K, Altun B, Altiparmak MR, Ecder T, Yilmaz ME, Çamsari T, Başçi A, Odabas AR, Serdengeçti K - Nephrol. Dial. Transplant. (2010)

Glomerular filtration rate (A), and microalbuminuria [as microalbuminuria (30–299 mg/g creatinine) or macroalbuminuria (> 300 mg/g creatinine)] (B) in subjects with and without concomitant hypertension, diabetes mellitus, dyslipidaemia, obesity or metabolic syndrome.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3107767&req=5

fig4: Glomerular filtration rate (A), and microalbuminuria [as microalbuminuria (30–299 mg/g creatinine) or macroalbuminuria (> 300 mg/g creatinine)] (B) in subjects with and without concomitant hypertension, diabetes mellitus, dyslipidaemia, obesity or metabolic syndrome.
Mentions: Mean values of kidney function and/or damage indicators, such as serum creatinine, GFR and microalbuminuria, in subjects with and without hypertension, diabetes, dyslipidaemia, obesity and metabolic syndrome also demonstrated that renal function in subjects with cardiovascular risk factors was significantly impaired compared with healthy individuals (Table 5). The prevalence of decreased GFR and microalbuminuria was higher in subjects having these risk factors, particularly in those having hypertension and diabetes (Figure 4). The prevalence of CKD among subjects with and without hypertension was 25.3% and 10.6%, respectively [P < 0.001, odds ratio 1.58 (95% CI: 1.48–1.68)]. Similarly, CKD was significantly more common in subjects with diabetes than in subjects without diabetes [32.4% vs. 13%; P < 0.001, odds ratio 1.22 (95% CI: 1.18–1.27)].

Bottom Line: The overall prevalence of CKD was 15.7%; it was higher in women than men (18.4% vs. 12.8%, P < 0.001) and increased with increasing age of the subjects.The prevalence of hypertension (32.7% in the general population), diabetes (12.7%), dyslipidaemia (76.3%), obesity (20.1%) and metabolic syndrome (31.3%) was significantly higher in subjects with CKD than subjects without CKD (P < 0.001 for all).The prevalence of CKD in Turkey is 15.7%.

View Article: PubMed Central - PubMed

Affiliation: Nephrology Division, Department of Medicine, Akdeniz University Medical School, Antalya, Turkey. gulteksu@superonline.com

ABSTRACT

Background: Chronic kidney disease (CKD) is a growing health problem worldwide that leads to end-stage kidney failure and cardiovascular complications. We aimed to determine the prevalence of CKD in Turkey, and to evaluate relationships between CKD and cardiovascular risk factors in a population-based survey.

Methods: Medical data were collected through home visits and interviews. Serum creatinine, blood glucose, total cholesterol, triglycerides, HDL, LDL and uric acid were determined from 12-h fasting blood samples, and spot urine tests were performed for subjects who gave consent to laboratory evaluation.

Results: A total of 10 872 participants were included in the study. The final analysis was performed on 10 748 subjects (mean age 40.5 ± 16.3 years; 55.7% women) and excluded 124 pregnant women. A low glomerular filtration rate (GFR) (< 60 mL/min/1.73 m(2)) was present in 5.2% of the subjects who were evaluated for GFR, while microalbuminuria and macroalbuminuria were observed in 10.2% and 2% of the subjects, respectively. The presence of CKD was assessed in subjects who gave consent for urinary albumin excretion measurement (n = 8765). The overall prevalence of CKD was 15.7%; it was higher in women than men (18.4% vs. 12.8%, P < 0.001) and increased with increasing age of the subjects. The prevalence of hypertension (32.7% in the general population), diabetes (12.7%), dyslipidaemia (76.3%), obesity (20.1%) and metabolic syndrome (31.3%) was significantly higher in subjects with CKD than subjects without CKD (P < 0.001 for all).

Conclusions: The prevalence of CKD in Turkey is 15.7%. Cardiovascular risk factors were significantly more prevalent in CKD patients.

Show MeSH
Related in: MedlinePlus