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Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH
Cumulative release of the sample with WTHF/WPLGA/WIBU = 85/12.5/2.5 in different release mediums, pH 7.4 phosphate buffered solution (-▪-) and pH 1.2 HCl aqueous solution (-•-).
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f6-ijn-6-659: Cumulative release of the sample with WTHF/WPLGA/WIBU = 85/12.5/2.5 in different release mediums, pH 7.4 phosphate buffered solution (-▪-) and pH 1.2 HCl aqueous solution (-•-).

Mentions: In order to better understand the importance of the release mediums on the drug release kinetics from PLGA-based films, the other two release mediums were chosen to mimic the in vitro release. Figure 6 shows the release profiles of the sample with WTHF/WPLGA/WIBU = 85/12.5/2.5 from the release mediums, HCl aqueous solution (pH 1.2) and PBS (pH 7.4). The time to reach 30% of drug release in PBS was 135 hours compared with 238 hours in HCl aqueous solution, which reveals that the drug release kinetic is faster at high pH than at low pH. The decreased release rate of IBU in acidic media (pH 1.2) may have been due to the decreased solubility of IBU. The pKa of IBU is known to be 4.42 and thus it has low aqueous solubility when the pH of the medium is below or close to 4.42. What is more, matrix erosion which is affected by medium pH is also expected to affect the drug release. It is known that PLGA hydrolysis is equilibrium-limited in acidic environments, while it is not limited by equilibrium in basic conditions. Thus the erosion of the matrix increases when the pH of the release medium increases.


Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Cumulative release of the sample with WTHF/WPLGA/WIBU = 85/12.5/2.5 in different release mediums, pH 7.4 phosphate buffered solution (-▪-) and pH 1.2 HCl aqueous solution (-•-).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107723&req=5

f6-ijn-6-659: Cumulative release of the sample with WTHF/WPLGA/WIBU = 85/12.5/2.5 in different release mediums, pH 7.4 phosphate buffered solution (-▪-) and pH 1.2 HCl aqueous solution (-•-).
Mentions: In order to better understand the importance of the release mediums on the drug release kinetics from PLGA-based films, the other two release mediums were chosen to mimic the in vitro release. Figure 6 shows the release profiles of the sample with WTHF/WPLGA/WIBU = 85/12.5/2.5 from the release mediums, HCl aqueous solution (pH 1.2) and PBS (pH 7.4). The time to reach 30% of drug release in PBS was 135 hours compared with 238 hours in HCl aqueous solution, which reveals that the drug release kinetic is faster at high pH than at low pH. The decreased release rate of IBU in acidic media (pH 1.2) may have been due to the decreased solubility of IBU. The pKa of IBU is known to be 4.42 and thus it has low aqueous solubility when the pH of the medium is below or close to 4.42. What is more, matrix erosion which is affected by medium pH is also expected to affect the drug release. It is known that PLGA hydrolysis is equilibrium-limited in acidic environments, while it is not limited by equilibrium in basic conditions. Thus the erosion of the matrix increases when the pH of the release medium increases.

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH