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Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

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Cumulative release of different samples in pH 6.8 phosphate buffered solution, films with ratios of WTHF/WPLGA/WIBU = 85/12.5/2.5 (-▪-), WTHF/WPLGA/WIBU = 85/11.25/3.75 (-•-), WTHF/WPLGA/WIBU = 85/10/5 (-▴-) and pure IBU (-▾-).Abbreviation: IBU, ibuprofen.
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f5-ijn-6-659: Cumulative release of different samples in pH 6.8 phosphate buffered solution, films with ratios of WTHF/WPLGA/WIBU = 85/12.5/2.5 (-▪-), WTHF/WPLGA/WIBU = 85/11.25/3.75 (-•-), WTHF/WPLGA/WIBU = 85/10/5 (-▴-) and pure IBU (-▾-).Abbreviation: IBU, ibuprofen.

Mentions: We examined the drug release behaviors of the as-prepared IBU-loaded PLGA films, in order to reveal their potential use in drug delivery systems. Figure 5 shows the release profiles of pure IBU and different ratios of WTHF/WPLGA/WIBU films in phosphate buffered solution (PBS, pH 6.8). Curve (a) shows that the pure IBU releases rapidly into the release medium with a release mount of nearly 100% in 12 hours. In contrast, in the sample with a ratio of WTHF/WPLGA/WIBU = 85/12.5/2.5, the release reached 12.7% ± 1.5% within 24 hours, and reached 32.4% ± 7.8% in 120 hours. In the sample with a ratio of WTHF/WPLGA/WIBU = 85/11.25/3.75, the release rate reached 27.5% ± 6.4% in 24 hours and 60% ± 5.5% in 120 hours. However, the release reached 46.6% ± 9.5% in 24 hours and 65.3% ± 1.6% in 120 hours in the sample with a ratio of WTHF/WPLGA/WIBU = 85/10/5. The different release percentages over the same time, show that the release rate decreases as the drug loading decreases. This can be due to the fewer drug molecules diffusing through the polymer network with the decrease of the drug loading. The polymer network becomes more porous as the drug concentration decreases, so that the soluble IBU molecules have to travel a longer distance from the pores to the release medium. The burst effect is not observed in the release, which can be explained as follows. On the one hand, the IBU is distributed homogeneously in the polymer without much surface segregation. On the other hand, rinsing the film decreases the amount of drug associated on the surface. These results show that a more controlled release can be obtained when changing the weight ratio of the drug, which indicates the potential application of the as-prepared drug-loaded PLGA products in a drug controlled delivery system.


Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Cumulative release of different samples in pH 6.8 phosphate buffered solution, films with ratios of WTHF/WPLGA/WIBU = 85/12.5/2.5 (-▪-), WTHF/WPLGA/WIBU = 85/11.25/3.75 (-•-), WTHF/WPLGA/WIBU = 85/10/5 (-▴-) and pure IBU (-▾-).Abbreviation: IBU, ibuprofen.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107723&req=5

f5-ijn-6-659: Cumulative release of different samples in pH 6.8 phosphate buffered solution, films with ratios of WTHF/WPLGA/WIBU = 85/12.5/2.5 (-▪-), WTHF/WPLGA/WIBU = 85/11.25/3.75 (-•-), WTHF/WPLGA/WIBU = 85/10/5 (-▴-) and pure IBU (-▾-).Abbreviation: IBU, ibuprofen.
Mentions: We examined the drug release behaviors of the as-prepared IBU-loaded PLGA films, in order to reveal their potential use in drug delivery systems. Figure 5 shows the release profiles of pure IBU and different ratios of WTHF/WPLGA/WIBU films in phosphate buffered solution (PBS, pH 6.8). Curve (a) shows that the pure IBU releases rapidly into the release medium with a release mount of nearly 100% in 12 hours. In contrast, in the sample with a ratio of WTHF/WPLGA/WIBU = 85/12.5/2.5, the release reached 12.7% ± 1.5% within 24 hours, and reached 32.4% ± 7.8% in 120 hours. In the sample with a ratio of WTHF/WPLGA/WIBU = 85/11.25/3.75, the release rate reached 27.5% ± 6.4% in 24 hours and 60% ± 5.5% in 120 hours. However, the release reached 46.6% ± 9.5% in 24 hours and 65.3% ± 1.6% in 120 hours in the sample with a ratio of WTHF/WPLGA/WIBU = 85/10/5. The different release percentages over the same time, show that the release rate decreases as the drug loading decreases. This can be due to the fewer drug molecules diffusing through the polymer network with the decrease of the drug loading. The polymer network becomes more porous as the drug concentration decreases, so that the soluble IBU molecules have to travel a longer distance from the pores to the release medium. The burst effect is not observed in the release, which can be explained as follows. On the one hand, the IBU is distributed homogeneously in the polymer without much surface segregation. On the other hand, rinsing the film decreases the amount of drug associated on the surface. These results show that a more controlled release can be obtained when changing the weight ratio of the drug, which indicates the potential application of the as-prepared drug-loaded PLGA products in a drug controlled delivery system.

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH