Limits...
Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH
DSC curves of PLGA (a), pure IBU (b), and IBU-loaded films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and (e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: DSC, differential scanning calorimetry; IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3107723&req=5

f4-ijn-6-659: DSC curves of PLGA (a), pure IBU (b), and IBU-loaded films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and (e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: DSC, differential scanning calorimetry; IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid).

Mentions: In order to further study the drug–polymer interaction, the DSC thermal characteristics of IBU-loaded PLGA films (c, d, and e) are compared with pure PLGA (a) and pure IBU (b) in Figure 4. The endothermic peak of PLGA (curve a) is observed at 56°C, which can be attributed to the glass-transition temperature of PLGA. The curve in Figure 4 shows a sharp endothermic peak at 78°C, which indicates that the melting peak of pure IBU is 78°C. The curves c, d, and e in Figure 4 show the peaks of different drug-loading films. Comparing with pure IBU, the melting points are 65, 75, and 73 for the samples of WTHF/WPLGA/WIBU = 85/12.5/2.5, WTHF/WPLGA/WIBU = 85/11.25/3.75 and WTHF/WPLGA/WIBU = 85/10/5, respectively. The shift of the melting point indicates a decrease of drug crystallinity. These results are consistent with the XRD analysis, which reveals that IBU is crystalline while PLGA is amorphous in the drug-loaded film.


Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

DSC curves of PLGA (a), pure IBU (b), and IBU-loaded films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and (e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: DSC, differential scanning calorimetry; IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107723&req=5

f4-ijn-6-659: DSC curves of PLGA (a), pure IBU (b), and IBU-loaded films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and (e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: DSC, differential scanning calorimetry; IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid).
Mentions: In order to further study the drug–polymer interaction, the DSC thermal characteristics of IBU-loaded PLGA films (c, d, and e) are compared with pure PLGA (a) and pure IBU (b) in Figure 4. The endothermic peak of PLGA (curve a) is observed at 56°C, which can be attributed to the glass-transition temperature of PLGA. The curve in Figure 4 shows a sharp endothermic peak at 78°C, which indicates that the melting peak of pure IBU is 78°C. The curves c, d, and e in Figure 4 show the peaks of different drug-loading films. Comparing with pure IBU, the melting points are 65, 75, and 73 for the samples of WTHF/WPLGA/WIBU = 85/12.5/2.5, WTHF/WPLGA/WIBU = 85/11.25/3.75 and WTHF/WPLGA/WIBU = 85/10/5, respectively. The shift of the melting point indicates a decrease of drug crystallinity. These results are consistent with the XRD analysis, which reveals that IBU is crystalline while PLGA is amorphous in the drug-loaded film.

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH