Limits...
Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH
XRD patterns of: a) pure IBU, b) PLGA, and IBU-loaded PLGA films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); XRD, X-ray diffraction.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3107723&req=5

f3-ijn-6-659: XRD patterns of: a) pure IBU, b) PLGA, and IBU-loaded PLGA films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); XRD, X-ray diffraction.

Mentions: X-ray diffraction (XRD) patterns were established on the pure IBU, pure PLGA, and the IBU-loaded PLGA films, in order to study the physical state of these systems. Generally, when the patterns of two crystal forms are identical in terms of peak positions, they have the same internal crystal structure, whereas if the patterns differ, the crystals have a different internal structure and are recognized as polymorphs.28 The XRD pattern of pure PLGA shown in Figure 3a has no evident brand, which denotes an amorphous polymeric compound. Figure 3b shows the XRD patterns of pure IBU, which yields typical peaks at 16°, 20°, and 22°, showing the crystalline substance. In the curves of IBU-loaded PLGA films shown in Figure 3c, d, and e, peaks at 16°, 20°, and 22° were detected in the three samples, which demonstrates that IBU had a crystalline state in the film. The difference in the relative intensity of the peaks is due either to the variation of the crystal habit, because the relative abundance of the planes exposed to X-ray source is altered, or to differences in the size of the crystals.28


Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

XRD patterns of: a) pure IBU, b) PLGA, and IBU-loaded PLGA films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); XRD, X-ray diffraction.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107723&req=5

f3-ijn-6-659: XRD patterns of: a) pure IBU, b) PLGA, and IBU-loaded PLGA films: c) WTHF/WPLGA/WIBU = 85/12.5/2.5; d) WTHF/WPLGA/WIBU = 85/11.25/3.75 and e) WTHF/WPLGA/WIBU = 85/10/5.Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); XRD, X-ray diffraction.
Mentions: X-ray diffraction (XRD) patterns were established on the pure IBU, pure PLGA, and the IBU-loaded PLGA films, in order to study the physical state of these systems. Generally, when the patterns of two crystal forms are identical in terms of peak positions, they have the same internal crystal structure, whereas if the patterns differ, the crystals have a different internal structure and are recognized as polymorphs.28 The XRD pattern of pure PLGA shown in Figure 3a has no evident brand, which denotes an amorphous polymeric compound. Figure 3b shows the XRD patterns of pure IBU, which yields typical peaks at 16°, 20°, and 22°, showing the crystalline substance. In the curves of IBU-loaded PLGA films shown in Figure 3c, d, and e, peaks at 16°, 20°, and 22° were detected in the three samples, which demonstrates that IBU had a crystalline state in the film. The difference in the relative intensity of the peaks is due either to the variation of the crystal habit, because the relative abundance of the planes exposed to X-ray source is altered, or to differences in the size of the crystals.28

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH