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Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

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SEM images of IBU-loaded PLGA films, WTHF/WPLGA/WIBU = 85/11.25/3.75 (A) and WTHF/WPLGA/WIBU = 85/10/5 (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.
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f2-ijn-6-659: SEM images of IBU-loaded PLGA films, WTHF/WPLGA/WIBU = 85/11.25/3.75 (A) and WTHF/WPLGA/WIBU = 85/10/5 (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.

Mentions: Figure 2 shows the SEM images of films with different ratios of WTHF/WPLGA/WIBU. Figure 2A shows the film with a ratio of WTHF/WPLGA/WIBU = 85/11.25/3.75. It shows that the film has a convex pattern on the top surface. The diameter of each convex shape is 0.87 ± 0.11 μm. The insert in Figure 2A shows the rough cross-section surface which indicates the presence of voids in the film. Figure 2B shows the film with a ratio of WTHF/WPLGA/WIBU = 85/10/5. The top surface is relatively smooth and has no convex pattern. Furthermore, the cross-section of the film is rough, which indicates that there are voids in the film.


Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

SEM images of IBU-loaded PLGA films, WTHF/WPLGA/WIBU = 85/11.25/3.75 (A) and WTHF/WPLGA/WIBU = 85/10/5 (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107723&req=5

f2-ijn-6-659: SEM images of IBU-loaded PLGA films, WTHF/WPLGA/WIBU = 85/11.25/3.75 (A) and WTHF/WPLGA/WIBU = 85/10/5 (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.
Mentions: Figure 2 shows the SEM images of films with different ratios of WTHF/WPLGA/WIBU. Figure 2A shows the film with a ratio of WTHF/WPLGA/WIBU = 85/11.25/3.75. It shows that the film has a convex pattern on the top surface. The diameter of each convex shape is 0.87 ± 0.11 μm. The insert in Figure 2A shows the rough cross-section surface which indicates the presence of voids in the film. Figure 2B shows the film with a ratio of WTHF/WPLGA/WIBU = 85/10/5. The top surface is relatively smooth and has no convex pattern. Furthermore, the cross-section of the film is rough, which indicates that there are voids in the film.

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH