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Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

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SEM images of IBU-loaded PLGA films WTHF/WPLGA/WIBU = 85/12.5/2.5), the surface (A), and the thickness (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.
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f1-ijn-6-659: SEM images of IBU-loaded PLGA films WTHF/WPLGA/WIBU = 85/12.5/2.5), the surface (A), and the thickness (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.

Mentions: Figure 1 shows SEM images of the IBU-loaded PLGA film with the ratio of WTHF/WPLGA/WIBU = 85/12.5/2.5.


Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.

Pang J, Luan Y, Li F, Cai X, Du J, Li Z - Int J Nanomedicine (2011)

SEM images of IBU-loaded PLGA films WTHF/WPLGA/WIBU = 85/12.5/2.5), the surface (A), and the thickness (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107723&req=5

f1-ijn-6-659: SEM images of IBU-loaded PLGA films WTHF/WPLGA/WIBU = 85/12.5/2.5), the surface (A), and the thickness (B).Abbreviations: IBU, ibuprofen; PLGA, poly(lactic-co-glycolic acid); SEM, scanning electron microscopy.
Mentions: Figure 1 shows SEM images of the IBU-loaded PLGA film with the ratio of WTHF/WPLGA/WIBU = 85/12.5/2.5.

Bottom Line: The results show the feasibility of the as-obtained films for controlling drug release.Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium.The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.

ABSTRACT
Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Show MeSH