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The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

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Structure of DHPS.
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f9-ijn-6-649: Structure of DHPS.

Mentions: DHPS (structure shown in Scheme 1) was synthesized in the laboratory,24 and isopropyl myristate (IPM) was bought from Shanghai LEASUN Chemical Co. Ltd (Shanghai, China). Various surfactants such as polyoxyethylene sorbitan fatty acid esters (Tween-80) and polyoxyethylenated castor oil (EL-40) were purchased from Tianjin Yongda Chemical Reagent Development Center (Tianjin, China). Methanol was chromatographically pure and purchased from Kangkede (Tianjin, China). Other chemical reagents were all analytically pure grades and purchased from Shijiazhuang Modern Reagent Co (Shijiazhuang, China). Soy bean salad oil, olive oil, and peanut oil were all of food grade and purchased from COFCO (Tianjin, China). Water was twice distilled.


The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

Structure of DHPS.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107722&req=5

f9-ijn-6-649: Structure of DHPS.
Mentions: DHPS (structure shown in Scheme 1) was synthesized in the laboratory,24 and isopropyl myristate (IPM) was bought from Shanghai LEASUN Chemical Co. Ltd (Shanghai, China). Various surfactants such as polyoxyethylene sorbitan fatty acid esters (Tween-80) and polyoxyethylenated castor oil (EL-40) were purchased from Tianjin Yongda Chemical Reagent Development Center (Tianjin, China). Methanol was chromatographically pure and purchased from Kangkede (Tianjin, China). Other chemical reagents were all analytically pure grades and purchased from Shijiazhuang Modern Reagent Co (Shijiazhuang, China). Soy bean salad oil, olive oil, and peanut oil were all of food grade and purchased from COFCO (Tianjin, China). Water was twice distilled.

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

Show MeSH