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The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

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The in vitro transdermal release of drug DHPS and DHPS nanoemulsion (n = 3).
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f8-ijn-6-649: The in vitro transdermal release of drug DHPS and DHPS nanoemulsion (n = 3).

Mentions: As seen from Figure 8, it is clear that DHPS released from nanoemulsion increases exponentially, while DHPS released from the drug suspension is rather low and almost constant. In a 12-hour period, the maximum accumulative osmotic quantity, Qt, of DHPS from the DHPS suspension is 8.02 μg · cm−2, while the Qt of DHPS from DHPS nanoemulsion is up to 273.15 μg · cm−2. During a defined time period, the transdermal release of DHPS from the suspension and the nanoemulsion follows the zero order kinetics equation, and the slope of the line indicates the penetration rate, J (Table 4). It is clear that the penetration rate, J, of DHPS is 0.53 μg · cm−2 · h−1 from the DHPS suspension, and 24.51 μg · cm−2 · h−1 from the DHPS nanoemulsion. Therefore, the DHPS nanoemulsion has demonstrated significant transdermal advantages.


The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

The in vitro transdermal release of drug DHPS and DHPS nanoemulsion (n = 3).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107722&req=5

f8-ijn-6-649: The in vitro transdermal release of drug DHPS and DHPS nanoemulsion (n = 3).
Mentions: As seen from Figure 8, it is clear that DHPS released from nanoemulsion increases exponentially, while DHPS released from the drug suspension is rather low and almost constant. In a 12-hour period, the maximum accumulative osmotic quantity, Qt, of DHPS from the DHPS suspension is 8.02 μg · cm−2, while the Qt of DHPS from DHPS nanoemulsion is up to 273.15 μg · cm−2. During a defined time period, the transdermal release of DHPS from the suspension and the nanoemulsion follows the zero order kinetics equation, and the slope of the line indicates the penetration rate, J (Table 4). It is clear that the penetration rate, J, of DHPS is 0.53 μg · cm−2 · h−1 from the DHPS suspension, and 24.51 μg · cm−2 · h−1 from the DHPS nanoemulsion. Therefore, the DHPS nanoemulsion has demonstrated significant transdermal advantages.

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

Show MeSH