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The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

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FT-Raman spectra.
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f7-ijn-6-649: FT-Raman spectra.

Mentions: DHPS and the DHPS nanoemulsion were detected by FT-Raman spectroscopy at laser 350 mW scanning from 50 cm−1 to 4000 cm−1. Because the surfactants and co-surfactants have no clear characteristic scattering absorbance, DHPS and the DHPS nanoemulsion have almost the same FT-Raman spectra. In Figure 7, the scattering characteristic peaks at 1453 cm−1 are attributed to the conjugating aromatic rings in stilbene and there is an alkene scattering peak at 1652 cm−1. The peaks from 2920 cm−1 to 2930 cm−1 and the peak at 1301 cm−1 indicate the i-propyl group of DHPS.


The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

FT-Raman spectra.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107722&req=5

f7-ijn-6-649: FT-Raman spectra.
Mentions: DHPS and the DHPS nanoemulsion were detected by FT-Raman spectroscopy at laser 350 mW scanning from 50 cm−1 to 4000 cm−1. Because the surfactants and co-surfactants have no clear characteristic scattering absorbance, DHPS and the DHPS nanoemulsion have almost the same FT-Raman spectra. In Figure 7, the scattering characteristic peaks at 1453 cm−1 are attributed to the conjugating aromatic rings in stilbene and there is an alkene scattering peak at 1652 cm−1. The peaks from 2920 cm−1 to 2930 cm−1 and the peak at 1301 cm−1 indicate the i-propyl group of DHPS.

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

Show MeSH