Limits...
The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

Show MeSH
The solubility of DHPS in various components.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3107722&req=5

f1-ijn-6-649: The solubility of DHPS in various components.

Mentions: As shown in Figure 1, DHPS is almost insoluble in distilled water and liquid paraffin, but has reasonable solubility in IPM, Tween-80, and EL-40. The solubility of the drug in the components is important for component screening,38 and therefore, IPM was selected as the oil phase, and Tween-80 and EL-40 were chosen as the surfactants in the nanoemulsion formulation. The four co-surfactants all have favorable solubility for DHPS, although of the four co-surfactants, ethanol had the most advantages. The emulsifier formulations consisted of surfactant (EL-40), co-surfactant (ethanol), and drug dissolved in the oil (IPM) to provide a clear liquid at ambient temperature. The test results showed that the emulsifier had extremely good solvent properties for DHPS. The solubility of DHPS in the emulsifier was elevated to about 60,000 times that in water.


The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Zhang Y, Gao J, Zheng H, Zhang R, Han Y - Int J Nanomedicine (2011)

The solubility of DHPS in various components.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107722&req=5

f1-ijn-6-649: The solubility of DHPS in various components.
Mentions: As shown in Figure 1, DHPS is almost insoluble in distilled water and liquid paraffin, but has reasonable solubility in IPM, Tween-80, and EL-40. The solubility of the drug in the components is important for component screening,38 and therefore, IPM was selected as the oil phase, and Tween-80 and EL-40 were chosen as the surfactants in the nanoemulsion formulation. The four co-surfactants all have favorable solubility for DHPS, although of the four co-surfactants, ethanol had the most advantages. The emulsifier formulations consisted of surfactant (EL-40), co-surfactant (ethanol), and drug dissolved in the oil (IPM) to provide a clear liquid at ambient temperature. The test results showed that the emulsifier had extremely good solvent properties for DHPS. The solubility of DHPS in the emulsifier was elevated to about 60,000 times that in water.

Bottom Line: The nanoemulsion was also determined by FT-Raman spectroscopy.The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties.The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

View Article: PubMed Central - PubMed

Affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.

ABSTRACT
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

Show MeSH