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Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies.

Farboud ES, Nasrollahi SA, Tabbakhi Z - Int J Nanomedicine (2011)

Bottom Line: A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20-30 years.In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream.In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. farbod@sina.tums.ac.ir

ABSTRACT
Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formulation of SLN dispersion consisted of 13% lipid (cetyl palmitate or stearic acid), 8% surfactant (Tween 80 or Tego Care 450), and water. Stability tests, particle size analysis, differential scanning calorimetry, transmission electron microscopy, and release study were conducted to find the best formulation. A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20-30 years. SLNs with particle size between 50 nm and100 nm exhibited the most suitable stability. In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream. In vitro release studies also demonstrated that CoQ10-loaded SLN and SLN cream possessed a biphasic release pattern in comparison with simple cream. In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.

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Related in: MedlinePlus

Percentage of released Q10 versus time for simple Q10, solid lipid nanoparticle (SLN), and Q10-loaded SLN cream.
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f5-ijn-6-611: Percentage of released Q10 versus time for simple Q10, solid lipid nanoparticle (SLN), and Q10-loaded SLN cream.

Mentions: As shown in Figures 4 and 5, the release of Q10 from SLN and SLN cream was faster than from simple cream. Due to the solid matrix of the nanoparticles and the subsequent drug immobilization, the release of encapsulated Q10 appeared different from that of Q10 cream. The PCS mean diameter of the SLN dispersion was 50 nm, whereas it was about 1 μm in the simple emulsion.


Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies.

Farboud ES, Nasrollahi SA, Tabbakhi Z - Int J Nanomedicine (2011)

Percentage of released Q10 versus time for simple Q10, solid lipid nanoparticle (SLN), and Q10-loaded SLN cream.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3107720&req=5

f5-ijn-6-611: Percentage of released Q10 versus time for simple Q10, solid lipid nanoparticle (SLN), and Q10-loaded SLN cream.
Mentions: As shown in Figures 4 and 5, the release of Q10 from SLN and SLN cream was faster than from simple cream. Due to the solid matrix of the nanoparticles and the subsequent drug immobilization, the release of encapsulated Q10 appeared different from that of Q10 cream. The PCS mean diameter of the SLN dispersion was 50 nm, whereas it was about 1 μm in the simple emulsion.

Bottom Line: A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20-30 years.In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream.In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. farbod@sina.tums.ac.ir

ABSTRACT
Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formulation of SLN dispersion consisted of 13% lipid (cetyl palmitate or stearic acid), 8% surfactant (Tween 80 or Tego Care 450), and water. Stability tests, particle size analysis, differential scanning calorimetry, transmission electron microscopy, and release study were conducted to find the best formulation. A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20-30 years. SLNs with particle size between 50 nm and100 nm exhibited the most suitable stability. In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream. In vitro release studies also demonstrated that CoQ10-loaded SLN and SLN cream possessed a biphasic release pattern in comparison with simple cream. In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.

Show MeSH
Related in: MedlinePlus