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Wall motion recovery in dobutamine stress magnetic resonance imaging

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To correlate the persistence of new or worsening induced wall motion abnormalities in dobutamine stress magnetic resonance imaging (DSMR) and the extent of coronary artery disease (CAD) in invasive coronary angiography... DSMR is a highly sensitive and specific non-invasive method for detecting induced wall motion abnormalities (IWMAs) in patients with significant CAD... Yet little is known about the duration of IWMA during the recovery period... We hypothesize that the persistence of IWMAs during recovery may be associated with the extent of CAD... DSMR was performed in twenty-eight consecutive patients with suspected or known CAD scheduled for clinically indicated invasive coronary angiography... All patients received esmolol after stopping the dobutamine infusion to achieve a heart rate under 100bpm... The recovery time was associated with more severe CAD... Our data showed that the higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p < 0.01, see figure 2)... The wall motion score index showed significant differences in territories supplied by arteries with intermediate stenoses compared with severe stenoses under maximum stress (difference wall motion score index ΔWMSI 0.19±0.27 vs. 0.37±0.32, p=0.03) and at five (ΔWMSI 0.05±0.11 vs. 0.22±0.26, p=0.007) and ten minutes (ΔWMSI 0.01±0.04 vs. 0.12±0.15, p=0.005) during recovery phase... Patients with intermediate and those with severe stenoses demonstrated no significant difference in the rate pressure product at maximum stress level (p=0,5), during recovery after five minutes (p=0.38) and ten minutes (p=0.16)... We demonstrated that normalization of left ventricular IWMAs is related to the extent of CAD.

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Significant difference of the Δ wall motion score index (ΔWMSI) at peak stress level (p=0.03), during recovery phase at 5 minutes (p=0.007) and 10 minutes (p=0.005) comparing intermediate and severe coronary artery stenosis. The higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p<0.01).
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Figure 2: Significant difference of the Δ wall motion score index (ΔWMSI) at peak stress level (p=0.03), during recovery phase at 5 minutes (p=0.007) and 10 minutes (p=0.005) comparing intermediate and severe coronary artery stenosis. The higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p<0.01).

Mentions: The recovery time was associated with more severe CAD. Our data showed that the higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p < 0.01, see figure 2).


Wall motion recovery in dobutamine stress magnetic resonance imaging
Significant difference of the Δ wall motion score index (ΔWMSI) at peak stress level (p=0.03), during recovery phase at 5 minutes (p=0.007) and 10 minutes (p=0.005) comparing intermediate and severe coronary artery stenosis. The higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p<0.01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3106559&req=5

Figure 2: Significant difference of the Δ wall motion score index (ΔWMSI) at peak stress level (p=0.03), during recovery phase at 5 minutes (p=0.007) and 10 minutes (p=0.005) comparing intermediate and severe coronary artery stenosis. The higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p<0.01).
Mentions: The recovery time was associated with more severe CAD. Our data showed that the higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p < 0.01, see figure 2).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

To correlate the persistence of new or worsening induced wall motion abnormalities in dobutamine stress magnetic resonance imaging (DSMR) and the extent of coronary artery disease (CAD) in invasive coronary angiography... DSMR is a highly sensitive and specific non-invasive method for detecting induced wall motion abnormalities (IWMAs) in patients with significant CAD... Yet little is known about the duration of IWMA during the recovery period... We hypothesize that the persistence of IWMAs during recovery may be associated with the extent of CAD... DSMR was performed in twenty-eight consecutive patients with suspected or known CAD scheduled for clinically indicated invasive coronary angiography... All patients received esmolol after stopping the dobutamine infusion to achieve a heart rate under 100bpm... The recovery time was associated with more severe CAD... Our data showed that the higher the wall motion score index was at peak stress, the longer IWMAs persisted during the recovery phase (p < 0.01, see figure 2)... The wall motion score index showed significant differences in territories supplied by arteries with intermediate stenoses compared with severe stenoses under maximum stress (difference wall motion score index ΔWMSI 0.19±0.27 vs. 0.37±0.32, p=0.03) and at five (ΔWMSI 0.05±0.11 vs. 0.22±0.26, p=0.007) and ten minutes (ΔWMSI 0.01±0.04 vs. 0.12±0.15, p=0.005) during recovery phase... Patients with intermediate and those with severe stenoses demonstrated no significant difference in the rate pressure product at maximum stress level (p=0,5), during recovery after five minutes (p=0.38) and ten minutes (p=0.16)... We demonstrated that normalization of left ventricular IWMAs is related to the extent of CAD.

No MeSH data available.


Related in: MedlinePlus