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Cardiopulmonary fitness, insulin sensitivity and myocardial fat: a CMR/MRS study in obese non-diabetic women

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In men, exercise training improves MTG, cardiac performance, physical fitness and insulin sensitivity... Given the gender difference in metabolic response to obesity these results cannot be simply extrapolated to women... Thus, it was the objective to explore the relation between cardiorespiratory fitness, cardiac function, and MTG in obese women... Insulin sensitivity given as composite insulin sensitivity index (c-ISI) was determined by oral glucose tolerance testing and maximum whole-body oxygen uptake as a measure of cardiopulmonary fitness by spiroergometry... In women with prediabetic (c-ISI < 4.5, n=29) vs. normal glucose tolerance (c-ISI > 4.5, n=36), MTG content was higher (0.83±0.30% vs. 0.61±0.23%, p=0.002) and cardiac diastolic function was impaired (1.32±0.44 vs. 1.55±0.46, p=0.047)... Age, 24h blood pressure and cardiopulmonary fitness (20±4 ml*min*kg vs. 22±5 ml*min*kg, p=0.32) were equal in both groups... In contrast, triglyceride levels in the skeletal muscle did not correlate to cardiopulmonary fitness in the study group (p>0.05), but correlated negatively with insulin sensitivity (r=-0.32, p=0.02)... In overweight and obese women, reduced cardiopulmonary fitness is associated with increased myocardial triglyceride content... Prediabetic glucose tolerance in obese females is associated with higher MTG and reduced diastolic function... Exercise-based life-style interventions could have a beneficial effect on cardiac function through myocardial triglyceride mobilization.

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Mentions: MTG content was negatively correlated with cardiopulmonary fitness (r=-0.28, p=0.02) in bivariate correlation analysis (Figure 2). In women with prediabetic (c-ISI < 4.5, n=29) vs. normal glucose tolerance (c-ISI > 4.5, n=36), MTG content was higher (0.83±0.30% vs. 0.61±0.23%, p=0.002) and cardiac diastolic function was impaired (1.32±0.44 vs. 1.55±0.46, p=0.047). Age, 24h blood pressure and cardiopulmonary fitness (20±4 ml*min-1*kg-1 vs. 22±5 ml*min-1*kg-1, p=0.32) were equal in both groups.


Cardiopulmonary fitness, insulin sensitivity and myocardial fat: a CMR/MRS study in obese non-diabetic women
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3106558&req=5

Mentions: MTG content was negatively correlated with cardiopulmonary fitness (r=-0.28, p=0.02) in bivariate correlation analysis (Figure 2). In women with prediabetic (c-ISI < 4.5, n=29) vs. normal glucose tolerance (c-ISI > 4.5, n=36), MTG content was higher (0.83±0.30% vs. 0.61±0.23%, p=0.002) and cardiac diastolic function was impaired (1.32±0.44 vs. 1.55±0.46, p=0.047). Age, 24h blood pressure and cardiopulmonary fitness (20±4 ml*min-1*kg-1 vs. 22±5 ml*min-1*kg-1, p=0.32) were equal in both groups.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

In men, exercise training improves MTG, cardiac performance, physical fitness and insulin sensitivity... Given the gender difference in metabolic response to obesity these results cannot be simply extrapolated to women... Thus, it was the objective to explore the relation between cardiorespiratory fitness, cardiac function, and MTG in obese women... Insulin sensitivity given as composite insulin sensitivity index (c-ISI) was determined by oral glucose tolerance testing and maximum whole-body oxygen uptake as a measure of cardiopulmonary fitness by spiroergometry... In women with prediabetic (c-ISI < 4.5, n=29) vs. normal glucose tolerance (c-ISI > 4.5, n=36), MTG content was higher (0.83±0.30% vs. 0.61±0.23%, p=0.002) and cardiac diastolic function was impaired (1.32±0.44 vs. 1.55±0.46, p=0.047)... Age, 24h blood pressure and cardiopulmonary fitness (20±4 ml*min*kg vs. 22±5 ml*min*kg, p=0.32) were equal in both groups... In contrast, triglyceride levels in the skeletal muscle did not correlate to cardiopulmonary fitness in the study group (p>0.05), but correlated negatively with insulin sensitivity (r=-0.32, p=0.02)... In overweight and obese women, reduced cardiopulmonary fitness is associated with increased myocardial triglyceride content... Prediabetic glucose tolerance in obese females is associated with higher MTG and reduced diastolic function... Exercise-based life-style interventions could have a beneficial effect on cardiac function through myocardial triglyceride mobilization.

No MeSH data available.