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Rapid flow assessment of congenital heart disease using high spatio-temporal gated spiral phase-contrast MR

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Many sick adults and children are unable to perform long breath-holds required for conventional, Cartesian phase-contrast (PC) sequences... Flow was measured in the: - Ascending aorta (AAO, N=40) - Main pulmonary artery (MPA, N=38) - Right pulmonary artery (RPA, N=22) - Left pulmonary artery (LPA, N=24) Flow assessment was performed in each vessel using the three sequences above (parameters shown in Table 1)... Stroke volume and regurgitation fraction were calculated for each patient... Additionally, Qp/Qs (N=38) and RPA/LPA (N=20) ratios were quantified where possible... Average scan time was 91±17 seconds for the reference free-breathing sequence, 16±3 seconds for the standard breath-hold sequence, and 5±1 seconds for the spiral breath-hold sequence... Combining all vessels (N=124), there were no statistical differences in mean stroke volume calculated from the reference free-breathing sequence (60.3±27.3 mL), the standard breath-hold sequence (59.8±27.6 mL) and the spiral breath-hold sequence (59.5±27.1 mL)... Bland-Altman analyses are shown in Figure 1... There was also an excellent agreement in QP/QS and RPA/LPA ratios between all sequences, however the spiral breath-hold sequence was found to be superior to the standard breath-hold sequence in terms of limits of agreement and correlation... Flow volumes can be accurately and reliably quantified using a spiral SENSE PCMR sequence, with high spatio-temporal resolution in a short breath-hold... As the standard method of measuring flow in congenital heart disease is free-breathing, cardiac gated PCMR, this spiral sequence could reduce total flow imaging from ~10 minutes, to <1 minute... This is a marked reduction in total scan time and has implications for patient throughput and compliance for congenital cardiac MR scanning.

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Mentions: Combining all vessels (N=124), there were no statistical differences in mean stroke volume calculated from the reference free-breathing sequence (60.3±27.3 mL), the standard breath-hold sequence (59.8±27.6 mL) and the spiral breath-hold sequence (59.5±27.1 mL). Bland-Altman analyses are shown in Figure 1. There was no clinically significant bias using either breath-hold sequence (spiral breath-hold: -0.7 mL, standard breath-hold: -0.5 mL). However, the limits of agreement were smaller and the correlation better for the spiral breath-hold compared to the standard breath-hold sequence (-4.4 to 2.9 mL vs. -10.3 to 9.3 mL, respectively).


Rapid flow assessment of congenital heart disease using high spatio-temporal gated spiral phase-contrast MR
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3106557&req=5

Mentions: Combining all vessels (N=124), there were no statistical differences in mean stroke volume calculated from the reference free-breathing sequence (60.3±27.3 mL), the standard breath-hold sequence (59.8±27.6 mL) and the spiral breath-hold sequence (59.5±27.1 mL). Bland-Altman analyses are shown in Figure 1. There was no clinically significant bias using either breath-hold sequence (spiral breath-hold: -0.7 mL, standard breath-hold: -0.5 mL). However, the limits of agreement were smaller and the correlation better for the spiral breath-hold compared to the standard breath-hold sequence (-4.4 to 2.9 mL vs. -10.3 to 9.3 mL, respectively).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Many sick adults and children are unable to perform long breath-holds required for conventional, Cartesian phase-contrast (PC) sequences... Flow was measured in the: - Ascending aorta (AAO, N=40) - Main pulmonary artery (MPA, N=38) - Right pulmonary artery (RPA, N=22) - Left pulmonary artery (LPA, N=24) Flow assessment was performed in each vessel using the three sequences above (parameters shown in Table 1)... Stroke volume and regurgitation fraction were calculated for each patient... Additionally, Qp/Qs (N=38) and RPA/LPA (N=20) ratios were quantified where possible... Average scan time was 91±17 seconds for the reference free-breathing sequence, 16±3 seconds for the standard breath-hold sequence, and 5±1 seconds for the spiral breath-hold sequence... Combining all vessels (N=124), there were no statistical differences in mean stroke volume calculated from the reference free-breathing sequence (60.3±27.3 mL), the standard breath-hold sequence (59.8±27.6 mL) and the spiral breath-hold sequence (59.5±27.1 mL)... Bland-Altman analyses are shown in Figure 1... There was also an excellent agreement in QP/QS and RPA/LPA ratios between all sequences, however the spiral breath-hold sequence was found to be superior to the standard breath-hold sequence in terms of limits of agreement and correlation... Flow volumes can be accurately and reliably quantified using a spiral SENSE PCMR sequence, with high spatio-temporal resolution in a short breath-hold... As the standard method of measuring flow in congenital heart disease is free-breathing, cardiac gated PCMR, this spiral sequence could reduce total flow imaging from ~10 minutes, to <1 minute... This is a marked reduction in total scan time and has implications for patient throughput and compliance for congenital cardiac MR scanning.

No MeSH data available.