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Does measurement of exercise/rest calf muscle perfusion reserve with first-pass contrast-enhanced MRI in peripheral arterial disease perform better than exercise-only perfusion ?

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Perfusion index (PI) measured by contrast-enhanced exercise calf perfusion MRI distinguishes normal subjects from those with PAD... Time-intensity curves (TIC) were generated using ARGUS software (Siemens) for arterial input and the muscle group with the highest signal intensity (tissue function, TF)... PI was measured as ratio of the slopes of the TF TIC/arterial input TIC... PR was defined as exercise TF/resting TF... PIR was calculated as exercise PI/rest PI... See Figure 1 for Bland Altman limits of agreement for exercise PI... The ICC for rest PI improved with normalization (0.64 vs 0.77)... The ICC for PR and PIR were weaker than for PI... Exercise PI remains the most reproducible measurement for quantification of exercise calf perfusion and does not require signal normalization under these experimental conditions.

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land Altman plot of Exercise PI
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Figure 1: land Altman plot of Exercise PI

Mentions: For normal and PAD patients with repeat studies, intraclass correlation (ICC) for exercise PI was similar for both normalized and non-normalized measurements (Table 1). See Figure 1 for Bland Altman limits of agreement for exercise PI. The ICC for rest PI improved with normalization (0.64 vs 0.77). The ICC for PR and PIR were weaker than for PI.


Does measurement of exercise/rest calf muscle perfusion reserve with first-pass contrast-enhanced MRI in peripheral arterial disease perform better than exercise-only perfusion ?
land Altman plot of Exercise PI
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3106543&req=5

Figure 1: land Altman plot of Exercise PI
Mentions: For normal and PAD patients with repeat studies, intraclass correlation (ICC) for exercise PI was similar for both normalized and non-normalized measurements (Table 1). See Figure 1 for Bland Altman limits of agreement for exercise PI. The ICC for rest PI improved with normalization (0.64 vs 0.77). The ICC for PR and PIR were weaker than for PI.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Perfusion index (PI) measured by contrast-enhanced exercise calf perfusion MRI distinguishes normal subjects from those with PAD... Time-intensity curves (TIC) were generated using ARGUS software (Siemens) for arterial input and the muscle group with the highest signal intensity (tissue function, TF)... PI was measured as ratio of the slopes of the TF TIC/arterial input TIC... PR was defined as exercise TF/resting TF... PIR was calculated as exercise PI/rest PI... See Figure 1 for Bland Altman limits of agreement for exercise PI... The ICC for rest PI improved with normalization (0.64 vs 0.77)... The ICC for PR and PIR were weaker than for PI... Exercise PI remains the most reproducible measurement for quantification of exercise calf perfusion and does not require signal normalization under these experimental conditions.

No MeSH data available.